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Adam Cryar et al.
Journal of AOAC International, 96(6), 1350-1361 (2014-03-22)
Current routine food allergen quantification methods, which are based on immunochemistry, offer high sensitivity but can suffer from issues of specificity and significant variability of results. MS approaches have been developed, but currently lack metrological traceability. A feasibility study on...
Ningbo Zhang et al.
Analytical chemistry, 84(14), 6206-6212 (2012-07-04)
As one of the most important platinum drugs, the interactions of cisplatin with proteins play very important roles in its anticancer action and side effects. Here, the interaction of cisplatin with cytochrome c was investigated using Fourier transform ion cyclotron...
Chuanfen Pu et al.
Food & function, 8(11), 4159-4169 (2017-10-13)
With the aim of exploring a natural antilisterial peptide from food-derived origin, an antibacterial peptide named as Alpep7 was purified from the bromelain hydrolysate of rice bran protein (RBP) in this study. The resulting amino acid consequence was identified as...
M Aghababaei et al.
Cell death and differentiation, 22(12), 1970-1984 (2015-04-25)
Trophoblasts, placental cells of epithelial lineage, undergo extensive differentiation to form the cellular components of the placenta. Trophoblast progenitor cell differentiation into the multinucleated syncytiotrophoblast is a key developmental process required for placental function, where defects in syncytiotrophoblast formation and...
Mina Rajabi et al.
Journal of biomolecular structure & dynamics, 37(17), 4557-4562 (2018-12-06)
Communicated by Ramaswamy H. Sarma.
Norelle L Daly et al.
The Journal of biological chemistry, 288(50), 36141-36148 (2013-10-31)
MCoTI-II is a head-to-tail cyclic peptide with potent trypsin inhibitory activity and, on the basis of its exceptional proteolytic stability, is a valuable template for the design of novel drug leads. Insights into inhibitor dynamics and interactions with biological targets...
Qian-Ru Zhao et al.
Journal of neurochemistry, 147(1), 40-57 (2018-06-20)
Neuritin is a neurotrophic factor that is activated by neural activity and neurotrophins. Its major function is to promote neurite growth and branching; however, the underlying mechanisms are not fully understood. To address this issue, this study investigated the effects...
Lisete Paiva et al.
Journal of food science, 82(7), 1757-1764 (2017-06-18)
This study presents information on the biochemical composition (dry weight basis), nutritional aspects, and angiotensin I-converting enzyme (ACE) inhibitory properties of selected macroalgae (Ulva compressa, Ulva rigida, Gelidium microdon, and Pterocladiella capillacea) from Azores. Moisture content was very high (83.2%...
Joyce Souza et al.
Experimental parasitology, 135(4), 701-707 (2013-11-05)
Trypsin and bile salts have been identified as important triggers for excystation of Echinostoma metacercariae. Although excystation in trematodes is a well-known phenomenon, some morphological developmental changes remain to be elucidated. In order to gain further insight into the in...
Fikadu G Tafesse et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6406-6411 (2013-04-12)
Cells genetically deficient in sphingomyelin synthase-1 (SGMS1) or blocked in their synthesis pharmacologically through exposure to a serine palmitoyltransferase inhibitor (myriocin) show strongly reduced surface display of influenza virus glycoproteins hemagglutinin (HA) and neuraminidase (NA). The transport of HA to...
Ying Zhang et al.
Molecular bioSystems, 9(3), 492-500 (2013-01-31)
As two of the most common and important post-translational modifications (PTMs) of proteins, glycosylation and phosphorylation play critical roles in biological processes. Because of the low abundance of phosphopeptides/glycopeptides, specific and sensitive strategies are especially indispensable for the identification of...
Sevdan Yılmaz et al.
Fish & shellfish immunology, 78, 140-157 (2018-04-24)
The present study investigated the effects of dietary trans-cinnamic acid (CA) on pre- and post-challenge haematological, serum biochemical, non-specific immune and head kidney gene expression responses of rainbow trout, Oncorhynchus mykiss juveniles. In this regard, fish with an average weight...
Treatment of proton pump inhibitor-resistant patients with gastroesophageal reflux disease.
Yoshikazu Kinoshita et al.
Journal of gastroenterology, 41(3), 286-287 (2006-05-16)
Nashwa H Kamel et al.
Journal of the Egyptian Society of Parasitology, 43(1), 245-258 (2013-05-24)
This work monitored changes in some digestive enzymes (trypsin and aminopeptidase) associated with the building up of resistance in Cx. pipiens larvae to two chemical insecticides (methomyl and/or malathion) and one biological insecticide (Bacillus thuringiensis-H14 or B.t H 14). The...
Sergei A Grigoryev et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(32), 13317-13322 (2009-08-05)
The architecture of the chromatin fiber, which determines DNA accessibility for transcription and other template-directed biological processes, remains unknown. Here we investigate the internal organization of the 30-nm chromatin fiber, combining Monte Carlo simulations of nucleosome chain folding with EM-assisted...
Vittorio Limongelli et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6358-6363 (2013-04-05)
A detailed description of the events ruling ligand/protein interaction and an accurate estimation of the drug affinity to its target is of great help in speeding drug discovery strategies. We have developed a metadynamics-based approach, named funnel metadynamics, that allows...
Antonio Jesús Vizcaíno et al.
Marine drugs, 18(6) (2020-06-24)
This piece of research evaluates the presence of protease inhibitors in the macroalga Ulva ohnoi and provides an initial overview of their mode of action. The ability of Ulva protease inhibitors to inhibit digestive proteases of three marine fish species...
Usman Bacha et al.
Chemical biology & drug design, 72(1), 34-49 (2008-07-10)
Coronaviruses comprise a large group of RNA viruses with diverse host specificity. The emergence of highly pathogenic strains like the SARS coronavirus (SARS-CoV), and the discovery of two new coronaviruses, NL-63 and HKU1, corroborates the high rate of mutation and...
R J Read et al.
Biochemistry, 23(26), 6570-6575 (1984-12-18)
The X-ray crystal structure of Streptomyces griseus trypsin has been solved and refined at 1.7-A resolution. The structure of this protein had been predicted in two models on the basis of its expected homology to structures of bovine trypsin and...
Bo Zhang et al.
Tumori, 98(6), 800-803 (2013-02-08)
As a powerful technique allowing analysis of large numbers of cells, fluorescence-activated cell sorting (FACS) is used more and more widely. For FACS analysis, adherent cells are usually detached by trypsinization, followed by centrifugation and resuspension. However, trypsinization can cut...
Simon J North et al.
Glycobiology, 22(1), 12-22 (2011-07-05)
In allergic diseases such as asthma, eosinophils, basophils and mast cells, through release of preformed and newly generated mediators, granule proteins and cytokines, are recognized as key effector cells. While their surface protein phenotypes, mediator release profiles, ontogeny, cell trafficking...
Monika Gulia-Nuss et al.
PloS one, 6(5), e20401-e20401 (2011-06-08)
Mosquitoes are insects that vector many serious pathogens to humans and other vertebrates. Most mosquitoes must feed on the blood of a vertebrate host to produce eggs. In turn, multiple cycles of blood feeding promote frequent contacts with hosts and...
Paul P Geurink et al.
Journal of medicinal chemistry, 56(3), 1262-1275 (2013-01-17)
Proteasomes degrade the majority of proteins in mammalian cells by a concerted action of three distinct pairs of active sites. The chymotrypsin-like sites are targets of antimyeloma agents bortezomib and carfilzomib. Inhibitors of the trypsin-like site sensitize multiple myeloma cells...
Aatur D Singhi et al.
The American journal of surgical pathology, 38(3), 346-353 (2014-02-15)
Hereditary pancreatitis is an autosomal dominant disorder with 80% penetrance and variable expressivity. The vast majority of cases have been linked to mutations within the cationic trypsinogen gene, also referred to as serine protease 1 (PRSS1). Other than inheritance, PRSS1...
J L Parker-Cote et al.
Clinical toxicology (Philadelphia, Pa.), 52(2), 118-120 (2014-01-15)
CONTEXT. Antivenom is expensive and not always available, so alternative treatments are being investigated. OBJECTIVE. The efficacy of trypsin or rosmarinic acid (RA) in treating Micrurus fulvius in a murine model is determined. MATERIALS AND METHODS. randomized controlled blinded study....
Takehiro K Sato et al.
Nature chemical biology, 9(6), 383-389 (2013-04-09)
Perfringolysin O (PFO), a bacterial cholesterol-dependent cytolysin, binds a mammalian cell membrane, oligomerizes into a circular prepore complex (PPC) and forms a 250-Å transmembrane β-barrel pore in the cell membrane. Each PFO monomer has two sets of three short α-helices...
Geraldine Delbès et al.
Biology of reproduction, 80(2), 320-327 (2008-11-07)
Advances in treatment for testicular cancer that include the coadministration of bleomycin, etoposide, and cisplatin (BEP) have brought the cure rate to higher than 90%%. The goal of this study was to elucidate the impact of BEP treatment on gene...
Janina Boyken et al.
Neuron, 78(2), 285-297 (2013-04-30)
Neurotransmission involves calcium-triggered fusion of docked synaptic vesicles at specialized presynaptic release sites. While many of the participating proteins have been identified, the molecular composition of these sites has not been characterized comprehensively. Here, we report a procedure to biochemically...
Eric W Klee et al.
American journal of clinical pathology, 141(4), 527-533 (2014-03-13)
Harmonization of prostate-specific antigen (PSA) immunoassays is important for good patient care. The specificity of the antibodies used to detect circulating PSA could cause differences in the PSA measurements. We used mass spectrometry (MS) to quantitate the concentration of five...
Reduction in serine protease activity correlates with improved rosacea severity in a small, randomized pilot study of a topical serine protease inhibitor.
Aimee M Two et al.
The Journal of investigative dermatology, 134(4), 1143-1145 (2013-11-12)
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