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John B Jonnalagadda et al.
Journal of biomaterials science. Polymer edition, 26(7), 401-419 (2015-02-12)
In this study, poly(e-caprolactone)/polyglycolic acid (PCL/PGA) scaffolds for repairing articular cartilage were fabricated via solid-state cryomilling along with compression molding and porogen leaching. Four distinct scaffolds were fabricated using this approach by four independent cryomilling times. These scaffolds were assessed
Gang Huang et al.
Nutrition and cancer, 67(5), 847-856 (2015-06-30)
The form of selenium appears to be important for preventing cancer in humans. Here, we evaluated selenium levels in the serum and bone tissue samples from osteosarcoma patients using atomic absorption spectrometry. The in vitro effects of Se-methylselenocysteine (Se-MSC) on
M Iwaszko et al.
Clinical and experimental immunology, 182(3), 270-277 (2015-08-27)
Involvement of the non-classical human leucocyte antigen-E (HLA-E) in both innate and acquired immune response suggests its possible role in development of autoimmune pathologies. This study was undertaken to investigate relationships between the HLA-E gene single nucleotide polymorphisms (SNPs) and
Abel Jacobus Bronkhorst et al.
Biochimica et biophysica acta, 1863(1), 157-165 (2015-11-04)
The most prominent factor that delays the translation of cell-free DNA (cfDNA) analyses to clinical practice is the lack of knowledge regarding its origin and composition. The elucidation of the former is complicated by the seemingly random fluctuation of quantitative
Rishil J Kathawala et al.
Chinese journal of cancer, 34(3), 115-120 (2015-05-13)
ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) proteins are efflux transporters that couple the energy derived from ATP hydrolysis to the translocation of toxic substances and chemotherapeutic drugs out of cells. Cabazitaxel is a
Yulia Kaluzhny et al.
Alternatives to laboratory animals : ATLA, 43(2), 101-127 (2015-05-23)
The 7th Amendment to the EU Cosmetics Directive and the EU REACH Regulation have reinforced the need for in vitro ocular test methods. Validated in vitro ocular toxicity tests that can predict the human response to chemicals, cosmetics and other
Emile Alghoul et al.
STAR protocols, 2(3), 100677-100677 (2021-08-12)
Inducible biomolecular condensates play fundamental roles in cellular responses to intracellular and environmental cues. Knowledge about their composition is crucial to understand the functions that arise specifically from the assembly of condensates. This protocol combines an optogenetic and an efficient
Karolina Pulka-Ziach et al.
Chembiochem : a European journal of chemical biology, 16(2), 293-301 (2014-12-10)
Cyclic peptides containing redox-stable thioether bridges might provide a useful alternative to disulfide-bridged bioactive peptides. We report the effect of replacing the disulfide bridge with a lanthionine linkage in a 16-mer cyclic peptide that binds to death receptor 5 (DR5
Joseph N Jarvis et al.
PLoS pathogens, 11(4), e1004754-e1004754 (2015-04-09)
Understanding the host immune response during cryptococcal meningitis (CM) is of critical importance for the development of immunomodulatory therapies. We profiled the cerebrospinal fluid (CSF) immune-response in ninety patients with HIV-associated CM, and examined associations between immune phenotype and clinical
Sunniyat Rahman et al.
Environmental health perspectives, 123(5), 484-492 (2015-01-13)
Aberrant histone acetylation has been observed in carcinogenesis and cellular transformation associated with arsenic exposure; however, the molecular mechanisms and cellular outcomes of such changes are poorly understood. We investigated the impact of tolerated and toxic arsenic trioxide (As2O3) exposure
A Bobeva et al.
Medical and veterinary entomology, 29(3), 290-296 (2015-02-18)
Many biting midges of the genus Culicoides Latreille, 1809 (Diptera: Ceratopogonidae) are competent vectors of a diverse number of pathogens. The identification of their feeding behaviour and of vector-host associations is essential for understanding their transmission capacity. By applying two
Andreas Bitter et al.
Archives of toxicology, 89(11), 2089-2103 (2014-09-04)
In addition to its well-characterized role in the regulation of drug metabolism and transport by xenobiotics, pregnane X receptor (PXR) critically impacts on lipid homeostasis. In mice, both ligand-dependent activation and knockout of PXR were previously shown to promote hepatic
Xing-Long Zheng et al.
Biomedical materials (Bristol, England), 10(4), 045023-045023 (2015-08-21)
Using a decellularized liver matrix (DLM) to reengineer liver tissue is a promising therapy for end-stage liver disease. However, the limited supply of donor organs still hampers its potential clinical application, while a xenogenic decellularized matrix may bring a risk
Sarah Afshordel et al.
Pharmacological research, 91, 69-77 (2014-12-17)
Alterations in small GTPase mediated signal transduction pathways have emerged as a central step in the molecular pathogenesis of glioblastoma (GBM), the most common malignant brain tumor in adults. Farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP) are derived from mevalonate, whose production
Gerard Artigas et al.
Organic & biomolecular chemistry, 13(2), 452-464 (2014-11-06)
Tau pre-mRNA contains a stem-loop structure involved in the regulation of the alternative splicing of tau protein. We describe here a new family of Tau RNA ligands selected by dynamic combinatorial chemistry based on the combination of ametantrone with small
Magdy S Alabady et al.
PloS one, 10(8), e0134855-e0134855 (2015-08-05)
We describe restriction site associated RNA sequencing (RARseq), an RNAseq-based genotype by sequencing (GBS) method. It includes the construction of RNAseq libraries from double stranded cDNA digested with selected restriction enzymes. To test this, we constructed six single- and six-dual-digested
C A Alvarado-Gilis et al.
Journal of animal science, 93(6), 3101-3109 (2015-06-27)
Three methods for protection of PUFA against biohydrogenation by ruminal microorganisms were evaluated. In method 1 a blend of ground flaxseed, calcium oxide, and molasses was processed through a dry extruder. In method 2, a blend of ground flaxseed, soybean
Deep Chatterjee et al.
The Journal of biological chemistry, 290(26), 16415-16430 (2015-05-17)
Low levels of reactive oxygen species (ROS) act as important signaling molecules, but in excess they can damage biomolecules. ROS regulation is therefore of key importance. Several polyphenols in general and flavonoids in particular have the potential to generate hydroxyl
Yisheng Yang et al.
Gene expression patterns : GEP, 19(1-2), 45-51 (2015-07-30)
Lhx9 is a member of the LIM-homeodomain gene family necessary for the correct development of many organs including gonads, limbs, heart and the nervous system. In the context of limb development, Lhx9 has been implicated as an integrator for Fibroblast
Dries J H De Clercq et al.
Chembiochem : a European journal of chemical biology, 16(5), 834-843 (2015-02-18)
We report the evaluation of two alternative chemical dimerizer approaches aimed at increasing the sensitivity of MASPIT, a three-hybrid system that enables small-molecule target protein profiling in intact human cells. To circumvent the potential limitations related to the binding of
Rabia Soussi et al.
Brain structure & function, 220(4), 2449-2468 (2014-06-04)
In mesial temporal lobe epilepsy (MTLE), spontaneous seizures likely originate from a multi-structural epileptogenic zone, including several regions of the limbic system connected to the hippocampal formation. In this study, we investigate the structural connectivity between the supramammillary nucleus (SuM)
Jia Kang et al.
Water environment research : a research publication of the Water Environment Federation, 86(3), 223-231 (2014-04-17)
The relationship between soluble microbial products (SMPs) and extracellular polymeric substances is described, and the characteristics of SMPs in the biological wastewater treatment process, including molecular weight distribution, metal-chelating property, biodegradability, biotoxicity, and membrane fouling, are investigated. The SMPs produced
Sebastian Weiterer et al.
PloS one, 10(3), e0121748-e0121748 (2015-03-21)
Sepsis is a global burden and the primary cause of death in intensive care units worldwide. The pathophysiological changes induced by the host's systemic inflammatory response to infection are not yet fully understood. During sepsis, the immune system is confronted
K Trautwein-Weidner et al.
Mucosal immunology, 8(2), 221-231 (2014-07-10)
Interleukin-17 (IL-17)-mediated immunity has emerged as a crucial host defense mechanism against Candida albicans infections in mucosal tissues and the skin. The precise mechanism by which the IL-17 pathway prevents fungal outgrowth has not been clarified. Neutrophils are critical for
Junko Nio-Kobayashi et al.
Molecular human reproduction, 21(8), 645-654 (2015-05-25)
Intense macrophage infiltration is observed during luteolysis in various animals including women; however, we still do not know how macrophage infiltration into the human corpus luteum (CL) during luteolysis is regulated. In this study, we examined the expression, localization and
Zachary W Bent et al.
Infection and immunity, 83(7), 2672-2685 (2015-04-22)
Yersinia enterocolitica is typically considered an extracellular pathogen; however, during the course of an infection, a significant number of bacteria are stably maintained within host cell vacuoles. Little is known about this population and the role it plays during an
Yang Guo et al.
Journal of cellular and molecular medicine, 19(2), 340-350 (2014-10-22)
We previously established a role for HSP27 as a predictive marker for therapeutic response towards gemcitabine in pancreatic cancer. Here, we investigate the underlying mechanisms of HSP27-mediated gemcitabine sensitivity. Utilizing a pancreatic cancer cell model with stable HSP27 overexpression, cell
Angelo D'Alessandro et al.
Journal of translational medicine, 13, 253-253 (2015-08-06)
Metabolic derangement is a key hallmark of major traumatic injury. The recent introduction of mass spectrometry-based metabolomics technologies in the field of trauma shed new light on metabolic aberrations in plasma that are triggered by trauma and hemorrhagic shock. Alteration
Timothy M Martin et al.
The journal of gene medicine, 17(1-2), 14-32 (2015-02-11)
Design of efficient nonviral gene delivery systems is limited as a result of the rudimentary understanding of the specific molecules and processes that facilitate DNA transfer. Lipoplexes formed with Lipofectamine 2000 (LF2000) and plasmid-encoding green fluorescent protein (GFP) were delivered
Robert Tacke et al.
Scientific reports, 5, 10055-10055 (2015-06-20)
Tissue macrophages function to maintain homeostasis and regulate immune responses. While tissue macrophages derive from one of a small number of progenitor programs, the transcriptional requirements for site-specific macrophage subset development are more complex. We have identified a new tissue
页码 1 来自 37
页码 1 来自 37