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Tsang-Hai Huang et al.
Journal of applied physiology (Bethesda, Md. : 1985), 119(5), 517-526 (2015-07-15)
To investigate the effects of dietary methionine restriction (MetR) and endurance exercise on bone quality under a condition of estrogen deficiency, female Sprague-Dawley rats (36-wk-old) were assigned to a sham surgery group or one of five ovariectomized groups subjected to
A Kuo et al.
British journal of pharmacology, 172(2), 532-548 (2014-03-20)
For patients experiencing inadequate analgesia and intolerable opioid-related side effects on one strong opioid analgesic, pain relief with acceptable tolerability is often achieved by rotation to a second strong opioid. These observations suggest subtle pharmacodynamic differences between opioids in vivo.
Céleste-Élise Stephany et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(35), 11631-11640 (2014-08-29)
The closure of developmental critical periods consolidates neural circuitry but also limits recovery from early abnormal sensory experience. Degrading vision by one eye throughout a critical period both perturbs ocular dominance (OD) in primary visual cortex and impairs visual acuity
Yunfeng Li et al.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 20(6), 1114-1121 (2015-09-13)
Semaphorin 3A (Sema3A) was demonstrated to exert an osteoprotective effect by both inhibiting osteoclastic bone resorption and promoting osteoblastic bone formation. The effect of Sema3A on fracture healing of osteoporotic rats was investigated in this study. Twelve weeks after bilateral
Andres F Zuluaga et al.
Journal of biomedical science, 22, 24-24 (2015-04-19)
Experimental models of pneumonia with penicillin non-susceptible Streptococcus pneumoniae (PNSSP) are hard to reproduce because the majority of strains with clinical relevance (like serotypes 6B, 9 V and 19 F) have low murine virulence. By optimization of culture and inoculum
Xin Wang et al.
Chemical biology & drug design, 86(5), 1036-1048 (2015-04-10)
The ubiquitin-proteasome system (UPS) is increasingly recognized as a therapeutic target for the development of anticancer therapies. The success of the 20S proteasome core particle (20S CP) inhibitor bortezomib in the clinical management of multiple myeloma has raised the possibility
S A Choi et al.
Cancer gene therapy, 22(6), 302-311 (2015-05-30)
Pediatric brainstem glioma is an incurable malignancy because of its inoperability. As a result of their extensive tropism toward cancer and the possibility of autologous transplantation, human adipose-derived mesenchymal stem cells (hAT-MSC) are attractive vehicles to deliver therapeutic genes to
Rebecca Kulbida et al.
Brain structure & function, 220(5), 3067-3073 (2014-06-04)
Focal epilepsies often originate in the hippocampal formation of the temporal lobe (temporal lobe epilepsy) and are generally acquired after transient brain insults. Such insults induce cellular and structural reorganization processes of the hippocampus, referred to as epileptogenesis that finally
C C B Lima et al.
International endodontic journal, 48(5), 405-416 (2014-06-04)
To evaluate the biocompatibility of two pastes designed to fill the root canals of primary teeth. A study group of 54 mice received subcutaneous tissue implants of polyethylene tubes containing CTZ or calcium hydroxide paste or, as a negative control
M Uchihashi et al.
American journal of primatology, 77(5), 563-578 (2015-02-14)
The vaginal microbiome is believed to influence host health by providing protection from pathogens and influencing reproductive outcomes such as fertility and gestational length. In humans, age-associated declines in diversity of the vaginal microbiome occur in puberty and persist into
Fei Wang et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(8), G680-G687 (2015-08-22)
Both glucagon-like peptide-1 (GLP-1) and apolipoprotein A-IV (apoA-IV) are produced from the gut and enhance postprandial insulin secretion. This study investigated whether apoA-IV regulates nutrient-induced GLP-1 secretion and whether apoA-IV knockout causes compensatory GLP-1 release. Using lymph-fistula-mice, we first determined
Yusuke Murahata et al.
American journal of veterinary research, 73(12), 1871-1880 (2012-11-28)
To investigate dose-related diuretic effects of medetomidine hydrochloride and xylazine hydrochloride in healthy cats. 5 sexually intact cats (4 males and 1 female). The 5 cats received each of 11 treatments. Cats were treated by IM administration of saline (0.9%
Hongyu Ying et al.
BMC cell biology, 16, 14-14 (2015-05-07)
Optineurin is a gene associated with normal tension glaucoma and amyotrophic lateral sclerosis. It has been reported previously that in cultured RGC5 cells, the turnover of endogenous optineurin involves mainly the ubiquitin-proteasome pathway (UPP). When optineurin is upregulated or mutated
Jong Min Lee et al.
Biomaterials, 39, 173-181 (2014-12-04)
A new design concept in controlled release chemistry is reported in this study. Unlike current depots that release drugs in all direction by an isotropic way, we demonstrate that directional release only to a clinically beneficial direction results in improved
Yun Tian et al.
Molecular brain, 8(1), 70-70 (2015-11-02)
Vacuolar protein sorting 35 (VPS35), a key component of retromer, plays an important role in endosome-to-Golgi retrieval of membrane proteins. Dysfunction of VPS35/retromer is a risk factor for neurodegenerative disorders, including AD (Alzheimer's disease) and PD (Parkinson's disease). However, exactly
Kisuk Yang et al.
Biomaterials, 63, 177-188 (2015-06-27)
Paracrine signals produced from stem cells influence tissue regeneration by inducing the differentiation of endogenous stem or progenitor cells. However, many recent studies that have investigated paracrine signaling of stem cells have relied on either two-dimensional transwell systems or conditioned
Priya Murugesan et al.
Hypertension (Dallas, Tex. : 1979), 66(4), 906-912 (2015-08-26)
This study examined whether the kinin B1 receptor is involved in the pathogenesis of pulmonary hypertension, and whether its inhibition could reduce inflammation, pulmonary hypertension, vascular remodeling, and right heart dysfunction. Male Wistar rats underwent left pneumonectomy. Seven days later
Jadwiga Oczos et al.
Investigative ophthalmology & visual science, 55(8), 4714-4727 (2014-07-17)
Biochemical and genetic analyses established a contribution of lipid metabolism to AMD pathology. Paraoxonase 1 (PON1) is an antioxidative protein involved in high density lipoprotein (HDL) function and was found to be associated with AMD. Here, we used Pon1(-/-) mice
Hyang Mok Ok et al.
Calcified tissue international, 97(6), 624-633 (2015-09-01)
The aim of this study was to evaluate the effects of a supplement containing Pueraria lobata/Rehmannia glutinosa (PR) root extracts on bone turnover in ovariectomized (OVX) rats (a model for postmenopausal osteoporosis). Female Sprague-Dawley rats (8 weeks old) were randomized
P Grachev et al.
Endocrinology, 155(7), 2589-2601 (2014-04-09)
Acute systemic stress disrupts reproductive function by inhibiting pulsatile gonadotropin secretion. The underlying mechanism involves stress-induced suppression of the GnRH pulse generator, the functional unit of which is considered to be the hypothalamic arcuate nucleus kisspeptin/neurokinin B/dynorphin A neurons. Agonists
Benedicta E Beck-Broichsitter et al.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 43(6), 981-988 (2015-05-16)
The timing of application of recombinant human bone morphogenic protein-2 (rhBMP-2) may be important in determining the final outcome of engineered bone tissue. This study investigates the impact of repetitive rhBMP-2 application on hard and soft tissue morphology in endocultivation.
Qi-Gang Zhou et al.
The Journal of clinical investigation, 129(1), 310-323 (2018-12-07)
We investigated how pathological changes in newborn hippocampal dentate granule cells (DGCs) lead to epilepsy. Using a rabies virus-mediated retrograde tracing system and a designer receptors exclusively activated by designer drugs (DREADD) chemogenetic method, we demonstrated that newborn hippocampal DGCs
Priscylla Gonçalves Correia-Leite de Marcelos et al.
Acta histochemica, 117(6), 582-589 (2015-06-15)
To verify whether the use of fluoxetine during gestation and lactation interferes in mandibular bone formation in rats. Twenty-four Wistar rat pups were used and distributed into four groups: CG - control of gestation; CL - control of gestation and
Giuseppe Gangarossa et al.
Hippocampus, 24(12), 1466-1481 (2014-07-22)
The acute activation of the dopamine D1-like receptors (D1R) is involved in a plethora of functions ranging from increased locomotor activity to the facilitation of consolidation, storage, and retrieval of memories. Although much less characterized, epileptiform activities, usually triggered by
J-Y Jo et al.
International journal of oral and maxillofacial surgery, 44(7), 921-928 (2015-03-15)
To investigate the effect of the sequential delivery of bone morphogenetic proteins BMP-2 and BMP-7 on bone regeneration in rat calvarial defects (40 Sprague-Dawley rats, 8mm defect size), all animals were treated with a hydroxyapatite (HA)/tricalcium phosphate (TCP) bone graft
Daniel Cai et al.
The American journal of pathology, 184(10), 2662-2670 (2014-08-08)
Diabetic corneal neuropathy can result in chronic, sight-threatening corneal pathology. Although the exact etiology is unknown, it is believed that a reduction in corneal sensitivity and loss of neurotrophic support contributes to corneal disease. Information regarding the relationship between nerve
Paschalis Theotokis et al.
Glia, 63(10), 1772-1783 (2015-04-29)
Exogenous transplanted neural precursor cells (NPCs) exhibit miscellaneous immune-modulatory effects in models of autoimmune demyelination. However, the regional interactions of NPCs with the host brain tissue in remissive inflammatory events have not been adequately studied. In this study we used
Tomoaki Fukui et al.
Cell transplantation, 24(7), 1379-1393 (2014-05-08)
We recently demonstrated that the local transplantation of human peripheral blood (PB) CD34(+) cells, an endothelial/hematopoietic progenitor cell-rich population, contributes to fracture repair via vasculogenesis/angiogenesis and osteogenesis. Human PB mononuclear cells (MNCs) are also considered a potential cell fraction for
Hyo-Jung Lee et al.
Journal of periodontal & implant science, 45(3), 94-100 (2015-07-02)
The aim of this study was to investigate the combined effects of physical and chemical surface factors on in vivo bone responses by comparing chemically modified hydrophilic sandblasted, large-grit, acid-etched (modSLA) and anodically oxidized hydrophobic implant surfaces. Five modSLA implants
Anlong Liu et al.
Calcified tissue international, 97(6), 581-591 (2015-09-01)
Diabetic osteoporosis continues to surge worldwide, increasing the risk of fracture. We have previously demonstrated that haploinsufficiency of endogenous parathyroid hormone-related peptide (PTHrP) impairs fracture healing. However, whether an exogenous supply of PTHrP can repair bone damage and accelerate fracture
页码 1 来自 29
页码 1 来自 29