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Gianpaolo Carrafiello et al.
La Radiologia medica, 119(1), 75-82 (2013-11-16)
This study was done to evaluate the feasibility, effectiveness and safety of microwave (MW) ablation of lung tumours. Twenty-four patients underwent percutaneous MW ablation of 26 intraparenchymal pulmonary masses. All patients were judged to be inoperable on the basis of
Horng-Ruey Chua et al.
BioMed research international, 2014, 506479-506479 (2014-09-03)
The impact of isoosmolar versus low-osmolar contrast media (CM) administration on contrast-induced acute kidney injury (CI-AKI) and extended renal dysfunction (ERD) is unclear. We retrospectively examined incidences of CI-AKI and ERD in patients who received iodixanol (isoosmolar) versus iohexol (low-osmolar)
Christian K Mathiesen et al.
Virology, 458-459, 190-208 (2014-06-15)
Recently, cell culture systems producing hepatitis C virus particles (HCVcc) were developed. Establishment of serum-free culture conditions is expected to facilitate development of a whole-virus inactivated HCV vaccine. We describe generation of genotype 1-6 serum-free HCVcc (sf-HCVcc) from Huh7.5 hepatoma
Siva P Raman et al.
AJR. American journal of roentgenology, 204(1), W37-W42 (2014-12-30)
Pancreatic adenocarcinoma is a rapidly progressive malignancy characterized by its tendency for early metastatic spread. MDCT is the primary diagnostic modality for the preoperative staging of patients with pancreatic cancer, with an accuracy established in multiple studies. However, for a
Alessandro Mariani et al.
Developmental neurobiology, 75(1), 23-38 (2014-07-22)
The central nervous system (CNS) is extremely vulnerable to the toxic effects of environmental pollutants during development. Polybrominated diphenyl ethers (PBDEs) are persistent contaminants, increasingly present in the environment and in human tissues. Recent investigations identified a correlation between maternal
Mathieu Nonnenmacher et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(4), 675-682 (2015-01-15)
Directed evolution of adeno-associated virus (AAV) through successive rounds of phenotypic selection is a powerful method to isolate variants with improved properties from large libraries of capsid mutants. Importantly, AAV libraries used for directed evolution are based on the "natural"
Kartik Jhaveri et al.
AJR. American journal of roentgenology, 201(2), W292-W296 (2013-07-26)
The purpose of this study is to evaluate the interval growth, tumor recurrence, and metastatic disease occurrence of cystic renal cell carcinoma (RCC). Pre-and posttreatment imaging of 47 histologically proven cystic RCCs, with at least 6 months of pretreatment imaging
Yi Xie et al.
Gynecologic oncology, 135(2), 325-332 (2014-08-12)
Anti-angiogenesis therapies such as bevacizumab, the monoclonal antibody to vascular endothelial growth factor (VEGF), have been used against ovarian cancer, but transient and low peritoneal drug levels are likely a factor in treatment failure. We hypothesized that a single administration
J-Y Bang et al.
British journal of anaesthesia, 113(6), 993-1000 (2014-09-27)
Although both Acute Kidney Injury Network (AKIN) and risk, injury, failure, loss, and end-stage (RIFLE) kidney disease criteria are frequently used to diagnose acute kidney injury (AKI), they have rarely been compared in the diagnosis of AKI in patients undergoing
Hélène Raoult et al.
Radiology, 271(2), 524-533 (2014-01-31)
To assess time-resolved spin-labeled (SL) magnetic resonance (MR) angiographic imaging with a large acquisition time window over two cardiac cycles for characterization of cerebral arteriovenous malformations (AVMs). This study was institutional review board-approved. Sixteen patients presented with an AVM, provided
Sushmita Chakraborty et al.
Journal of immunology (Baltimore, Md. : 1950), 194(8), 3852-3860 (2015-03-20)
Leishmania major is a parasite that resides and replicates in macrophages. We previously showed that the parasite enhanced CD40-induced Raf-MEK-ERK signaling but inhibited PI3K-MKK-p38MAPK signaling to proleishmanial effects. As Raf and PI3K have a Ras-binding domain but exert opposite effects
G Sun et al.
Clinical radiology, 70(2), 138-145 (2014-12-04)
To evaluate the feasibility of using a reduced radiation dose and reduced iodine intake (i.e., "double low": low tube voltage/low iodine dose contrast agent) scanning protocol and the adaptive iterative dose reduction (AIDR) reconstruction algorithm in coronary heart disease (CHD)
Haibin Liu et al.
Journal of virology, 89(10), 5668-5686 (2015-03-13)
Japanese encephalitis virus (JEV), which causes viral encephalitis in humans, is a serious risk to global public health. The JEV envelope protein mediates the viral entry pathway, including receptor-binding and low-pH-triggered membrane fusion. Utilizing mutagenesis of a JEV infectious cDNA
Peter A McCullough
Expert review of cardiovascular therapy, 4(5), 655-661 (2006-11-04)
Iodinated contrast is a mainstay for diagnostic and interventional procedures performed by cardiologists, radiologists and other specialists. With the emergence of computed tomographic techniques for the evaluation of cardiac disease, malignancies, trauma and a variety of other internal disorders, the
Diana C Lenhard et al.
Investigative radiology, 49(12), 779-787 (2014-07-06)
The aim of this preclinical study on healthy Sprague-Dawley rats was to determine whether differences exist in the induction of adverse skin reactions after the intravenous administration of a monomeric and 2 dimeric iodinated nonionic contrast agents. After intravenous injection
Sebastian Reith et al.
Clinical research in cardiology : official journal of the German Cardiac Society, 104(1), 59-70 (2014-08-16)
Fractional flow reserve (FFR) measurements accurately assess functional relevance in intermediate grade coronary lesions. A significant relationship between hemodynamic stenosis severity and optical coherence tomography (OCT)-derived intraluminal dimensions has recently been demonstrated. However, morphologic thresholds to identify significant stenoses are
Hyun-Jung Jang et al.
AJR. American journal of roentgenology, 201(2), 314-321 (2013-07-26)
The purpose of this study was to identify the essential number of phases from multiphasic CT for 1- to 2-cm hepatocellular carcinoma (HCC) on surveillance ultrasound and to compare the results with the American Association for the Study of Liver
Jian Zhang et al.
Chinese medical journal, 128(6), 784-789 (2015-03-12)
Current randomized trials have demonstrated the effects of short-term rosuvastatin therapy in preventing contrast-induced acute kidney injury (CIAKI). However, the consistency of these effects on patients administered different volumes of contrast media is unknown. In the TRACK-D trial, 2998 patients
Sonja M Kandel et al.
Radiology, 270(1), 125-130 (2013-09-14)
To analyze the effect of the duration of contrast material bolus injection on perfusion values in a swine model by using the maximum slope method. This study was approved by the institutional animal care committee. Twenty pigs (weight range, 63-77
Marlene Hill et al.
Renal failure, 35(6), 791-795 (2013-05-30)
Contrast-induced acute kidney injury (CIAKI) is associated with an accelerated progression of underlying chronic kidney disease (CKD). We sought to characterize the rate of loss of kidney function following fistulography in patients with advanced CKD. We identified all patients with
Tong-qiang Liu et al.
Oxidative medicine and cellular longevity, 2014, 427560-427560 (2014-12-06)
Contrast-induced acute kidney injury (CI-AKI) is a serious complication in patients after administration of iodinated contrast media. Proper animal models of CI-AKI can help understand the mechanisms involved and prevent the disorder. We used the 5/6-nephrectomized (NE) rat to develop
Zhi Zhao Liu et al.
American journal of physiology. Renal physiology, 306(8), F864-F872 (2014-01-17)
Iodinated contrast media (CM) have adverse effects that may result in contrast-induced acute kidney injury. Oxidative stress is believed to play a role in CM-induced kidney injury. We test the hypothesis that oxidative stress and reduced nitric oxide in tubules
Xiaochuan Wang et al.
Journal of Alzheimer's disease : JAD, 45(2), 423-435 (2015-01-16)
Protein phosphatase-2A (PP2A) deficiency is a cause of the abnormal hyperphosphorylation of tau, which composes neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) brain. We previously reported that both mRNA and protein expression of inhibitor I of PP2A (I(1)(PP2A)) are elevated
Adam J Guenzel et al.
Human gene therapy, 26(3), 153-160 (2015-02-06)
Propionic academia (PA) occurs because of mutations in the PCCA or PCCB genes encoding the two subunits of propionyl-CoA carboxylase, a pivotal enzyme in the breakdown of certain amino acids and odd-chain fatty acids. There is no cure for PA
Leah C Byrne et al.
The Journal of clinical investigation, 125(1), 105-116 (2014-11-22)
Alternative splicing of nucleoredoxin-like 1 (Nxnl1) results in 2 isoforms of the rod-derived cone viability factor. The truncated form (RdCVF) is a thioredoxin-like protein secreted by rods that promotes cone survival, while the full-length isoform (RdCVFL), which contains a thioredoxin
Jill Rachel Mains et al.
Investigative radiology, 49(9), 601-607 (2014-04-03)
The aim of this study was to explore the impact of dynamic contrast-enhanced (DCE) computer tomography (CT) as a biomarker in metastatic renal cell carcinoma (mRCC). Twelve patients with favorable or intermediate Memorial Sloan Kettering Cancer Center risk group and
Shanthi Vadali et al.
Journal of leukocyte biology, 96(5), 873-881 (2014-07-30)
SR-A mediated macrophage adhesion to modified ECM proteins in a process that involves physical attachment of SR-A to modified ECM and activation of Lyn-PI3K and PLA2-12/15-lipoxygenase signaling pathways. Structurally, SR-A-mediated cell adhesion requires a 6-aa membrane-proximal cytoplasmic motif. However, the
Juan Li et al.
Virology, 477, 82-88 (2015-02-11)
The role of envelope protein-linked N-glycans in porcine reproductive and respiratory syndrome virus (PRRSV) infection of permissive cells was examined. N-acetylglucosamine (GlcNAc) and N-acetyllactosamine (LacNAc) oligomer-specific lectins bound to PRRSV and blocked virus attachment, resulting in reduced viral infection. However
A Sasaki et al.
Journal of comparative pathology, 151(2-3), 264-270 (2014-08-05)
Fourteen renal biomarkers were compared with measurement of glomerular filtration rate (GFR) in detecting acute kidney injury (AKI) in beagle dogs given gentamicin (40 mg/kg/day by subcutaneous injection) for 7 consecutive days. Serum and urinary biomarkers were measured before administration
Vincent Vandecaveye et al.
Radiology, 270(3), 747-757 (2014-01-31)
To evaluate the predictive utility of apparent diffusion coefficient (ADC) changes at diffusion-weighted (DW) magnetic resonance (MR) imaging 1 month after transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) compared with the Response Evaluation Criteria in Solid Tumors (RECIST) version
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