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Mathieu Nonnenmacher et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(4), 675-682 (2015-01-15)
Directed evolution of adeno-associated virus (AAV) through successive rounds of phenotypic selection is a powerful method to isolate variants with improved properties from large libraries of capsid mutants. Importantly, AAV libraries used for directed evolution are based on the "natural"
Yi Xie et al.
Gynecologic oncology, 135(2), 325-332 (2014-08-12)
Anti-angiogenesis therapies such as bevacizumab, the monoclonal antibody to vascular endothelial growth factor (VEGF), have been used against ovarian cancer, but transient and low peritoneal drug levels are likely a factor in treatment failure. We hypothesized that a single administration
Gianpaolo Carrafiello et al.
La Radiologia medica, 119(1), 75-82 (2013-11-16)
This study was done to evaluate the feasibility, effectiveness and safety of microwave (MW) ablation of lung tumours. Twenty-four patients underwent percutaneous MW ablation of 26 intraparenchymal pulmonary masses. All patients were judged to be inoperable on the basis of
Siva P Raman et al.
AJR. American journal of roentgenology, 204(1), W37-W42 (2014-12-30)
Pancreatic adenocarcinoma is a rapidly progressive malignancy characterized by its tendency for early metastatic spread. MDCT is the primary diagnostic modality for the preoperative staging of patients with pancreatic cancer, with an accuracy established in multiple studies. However, for a
Alessandro Mariani et al.
Developmental neurobiology, 75(1), 23-38 (2014-07-22)
The central nervous system (CNS) is extremely vulnerable to the toxic effects of environmental pollutants during development. Polybrominated diphenyl ethers (PBDEs) are persistent contaminants, increasingly present in the environment and in human tissues. Recent investigations identified a correlation between maternal
G Sun et al.
Clinical radiology, 70(2), 138-145 (2014-12-04)
To evaluate the feasibility of using a reduced radiation dose and reduced iodine intake (i.e., "double low": low tube voltage/low iodine dose contrast agent) scanning protocol and the adaptive iterative dose reduction (AIDR) reconstruction algorithm in coronary heart disease (CHD)
Sushmita Chakraborty et al.
Journal of immunology (Baltimore, Md. : 1950), 194(8), 3852-3860 (2015-03-20)
Leishmania major is a parasite that resides and replicates in macrophages. We previously showed that the parasite enhanced CD40-induced Raf-MEK-ERK signaling but inhibited PI3K-MKK-p38MAPK signaling to proleishmanial effects. As Raf and PI3K have a Ras-binding domain but exert opposite effects
Kartik Jhaveri et al.
AJR. American journal of roentgenology, 201(2), W292-W296 (2013-07-26)
The purpose of this study is to evaluate the interval growth, tumor recurrence, and metastatic disease occurrence of cystic renal cell carcinoma (RCC). Pre-and posttreatment imaging of 47 histologically proven cystic RCCs, with at least 6 months of pretreatment imaging
Hyun-Jung Jang et al.
AJR. American journal of roentgenology, 201(2), 314-321 (2013-07-26)
The purpose of this study was to identify the essential number of phases from multiphasic CT for 1- to 2-cm hepatocellular carcinoma (HCC) on surveillance ultrasound and to compare the results with the American Association for the Study of Liver
Christian K Mathiesen et al.
Virology, 458-459, 190-208 (2014-06-15)
Recently, cell culture systems producing hepatitis C virus particles (HCVcc) were developed. Establishment of serum-free culture conditions is expected to facilitate development of a whole-virus inactivated HCV vaccine. We describe generation of genotype 1-6 serum-free HCVcc (sf-HCVcc) from Huh7.5 hepatoma
Peter A McCullough
Expert review of cardiovascular therapy, 4(5), 655-661 (2006-11-04)
Iodinated contrast is a mainstay for diagnostic and interventional procedures performed by cardiologists, radiologists and other specialists. With the emergence of computed tomographic techniques for the evaluation of cardiac disease, malignancies, trauma and a variety of other internal disorders, the
Haibin Liu et al.
Journal of virology, 89(10), 5668-5686 (2015-03-13)
Japanese encephalitis virus (JEV), which causes viral encephalitis in humans, is a serious risk to global public health. The JEV envelope protein mediates the viral entry pathway, including receptor-binding and low-pH-triggered membrane fusion. Utilizing mutagenesis of a JEV infectious cDNA
Horng-Ruey Chua et al.
BioMed research international, 2014, 506479-506479 (2014-09-03)
The impact of isoosmolar versus low-osmolar contrast media (CM) administration on contrast-induced acute kidney injury (CI-AKI) and extended renal dysfunction (ERD) is unclear. We retrospectively examined incidences of CI-AKI and ERD in patients who received iodixanol (isoosmolar) versus iohexol (low-osmolar)
Sebastian Reith et al.
Clinical research in cardiology : official journal of the German Cardiac Society, 104(1), 59-70 (2014-08-16)
Fractional flow reserve (FFR) measurements accurately assess functional relevance in intermediate grade coronary lesions. A significant relationship between hemodynamic stenosis severity and optical coherence tomography (OCT)-derived intraluminal dimensions has recently been demonstrated. However, morphologic thresholds to identify significant stenoses are
Jian Zhang et al.
Chinese medical journal, 128(6), 784-789 (2015-03-12)
Current randomized trials have demonstrated the effects of short-term rosuvastatin therapy in preventing contrast-induced acute kidney injury (CIAKI). However, the consistency of these effects on patients administered different volumes of contrast media is unknown. In the TRACK-D trial, 2998 patients
Marlene Hill et al.
Renal failure, 35(6), 791-795 (2013-05-30)
Contrast-induced acute kidney injury (CIAKI) is associated with an accelerated progression of underlying chronic kidney disease (CKD). We sought to characterize the rate of loss of kidney function following fistulography in patients with advanced CKD. We identified all patients with
Joshua Becker et al.
AJR. American journal of roentgenology, 200(4), 822-826 (2013-03-26)
The purpose of this study was to use measured glomerular filtration rate (GFR), the reference standard of renal function, to assess the deleterious effect of iodinated contrast media on renal function. Such an effect has been traditionally defined as a
Michael Reed et al.
JACC. Cardiovascular interventions, 2(7), 645-654 (2009-07-25)
We sought to compare the nephrotoxicity of the iso-osmolar contrast medium, iodixanol, to low-osmolar contrast media (LOCM). Contrast-induced acute kidney injury (CI-AKI) is a common cause of in-hospital renal failure. A prior meta-analysis suggested that iodixanol (Visipaque, GE Healthcare, Princeton
L Vadot et al.
Journal of clinical pharmacy and therapeutics, 40(1), 83-90 (2014-11-22)
Drug eluting beads (DEBs) theoretically improve the efficacy and safety of transarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC). Nonetheless, their economic profile has not been assessed. Our retrospective before/after study aimed to compare efficacy, safety and economic profile of two
Shanthi Vadali et al.
Journal of leukocyte biology, 96(5), 873-881 (2014-07-30)
SR-A mediated macrophage adhesion to modified ECM proteins in a process that involves physical attachment of SR-A to modified ECM and activation of Lyn-PI3K and PLA2-12/15-lipoxygenase signaling pathways. Structurally, SR-A-mediated cell adhesion requires a 6-aa membrane-proximal cytoplasmic motif. However, the
Successful rapid intravenous desensitization for radioiodine contrast allergy in a patient requiring urgent coronary angiography.
Sumeet Gandhi et al.
The journal of allergy and clinical immunology. In practice, 2(1), 101-102 (2014-02-26)
C H Houben et al.
Pediatric surgery international, 29(9), 953-955 (2013-07-17)
Neonatal cholestatic disorder in the late neonatal period requires often cholangiography to differentiate between biliary atresia and other causes of prolonged neonatal jaundice. A simplified method of a laparoscopic-assisted cholecysto-cholangiography is presented. Retrospective chart review was conducted of all patients
Xiaochuan Wang et al.
Journal of Alzheimer's disease : JAD, 45(2), 423-435 (2015-01-16)
Protein phosphatase-2A (PP2A) deficiency is a cause of the abnormal hyperphosphorylation of tau, which composes neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) brain. We previously reported that both mRNA and protein expression of inhibitor I of PP2A (I(1)(PP2A)) are elevated
Zhi Zhao Liu et al.
American journal of physiology. Renal physiology, 306(8), F864-F872 (2014-01-17)
Iodinated contrast media (CM) have adverse effects that may result in contrast-induced acute kidney injury. Oxidative stress is believed to play a role in CM-induced kidney injury. We test the hypothesis that oxidative stress and reduced nitric oxide in tubules
Adam J Guenzel et al.
Human gene therapy, 26(3), 153-160 (2015-02-06)
Propionic academia (PA) occurs because of mutations in the PCCA or PCCB genes encoding the two subunits of propionyl-CoA carboxylase, a pivotal enzyme in the breakdown of certain amino acids and odd-chain fatty acids. There is no cure for PA
A Sasaki et al.
Journal of comparative pathology, 151(2-3), 264-270 (2014-08-05)
Fourteen renal biomarkers were compared with measurement of glomerular filtration rate (GFR) in detecting acute kidney injury (AKI) in beagle dogs given gentamicin (40 mg/kg/day by subcutaneous injection) for 7 consecutive days. Serum and urinary biomarkers were measured before administration
Mark M McDonald et al.
Stroke, 45(2), 462-466 (2013-12-29)
Iodinated contrast agents used for computed tomography angiography (CTA) may alter fibrin fiber characteristics and decrease fibrinolysis by tissue plasminogen activator (tPA). Thromboelastography (TEG) measures the dynamics of coagulation and correlates with thrombolysis in acute ischemic stroke patients. We hypothesized
Juan Li et al.
Virology, 477, 82-88 (2015-02-11)
The role of envelope protein-linked N-glycans in porcine reproductive and respiratory syndrome virus (PRRSV) infection of permissive cells was examined. N-acetylglucosamine (GlcNAc) and N-acetyllactosamine (LacNAc) oligomer-specific lectins bound to PRRSV and blocked virus attachment, resulting in reduced viral infection. However
Jill Rachel Mains et al.
Investigative radiology, 49(9), 601-607 (2014-04-03)
The aim of this study was to explore the impact of dynamic contrast-enhanced (DCE) computer tomography (CT) as a biomarker in metastatic renal cell carcinoma (mRCC). Twelve patients with favorable or intermediate Memorial Sloan Kettering Cancer Center risk group and
Leah C Byrne et al.
The Journal of clinical investigation, 125(1), 105-116 (2014-11-22)
Alternative splicing of nucleoredoxin-like 1 (Nxnl1) results in 2 isoforms of the rod-derived cone viability factor. The truncated form (RdCVF) is a thioredoxin-like protein secreted by rods that promotes cone survival, while the full-length isoform (RdCVFL), which contains a thioredoxin
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