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  • Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase.

Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase.

Biochemistry (2016-08-11)
Matthew J Kolar, Siddhesh S Kamat, William H Parsons, Edwin A Homan, Tim Maher, Odile D Peroni, Ismail Syed, Karianne Fjeld, Anders Molven, Barbara B Kahn, Benjamin F Cravatt, Alan Saghatelian
摘要

A recently discovered class of endogenous mammalian lipids, branched fatty acid esters of hydroxy fatty acids (FAHFAs), possesses anti-diabetic and anti-inflammatory activities. Here, we identified and validated carboxyl ester lipase (CEL), a pancreatic enzyme hydrolyzing cholesteryl esters and other dietary lipids, as a FAHFA hydrolase. Variants of CEL have been linked to maturity-onset diabetes of the young, type 8 (MODY8), and to chronic pancreatitis. We tested the FAHFA hydrolysis activity of the CEL MODY8 variant and found a modest increase in activity as compared with that of the normal enzyme. Together, the data suggest that CEL might break down dietary FAHFAs.

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L-甲硫氨酸甲酯 盐酸盐, 98%
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石墨烯纳米微片, 5 μm particle size, surface area 50-80 m2/g
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石墨烯纳米微片, 15 μm particle size, surface area 50-80 m2/g