Merck
  • Local exposure of 849 MHz and 1763 MHz radiofrequency radiation to mouse heads does not induce cell death or cell proliferation in brain.

Local exposure of 849 MHz and 1763 MHz radiofrequency radiation to mouse heads does not induce cell death or cell proliferation in brain.

Experimental & molecular medicine (2008-07-01)
Tae-Hyung Kim, Tae-Hyoung Kim, Tai-Qin Huang, Ja-June Jang, Man Ho Kim, Hyun-Jeong Kim, Jae-Seon Lee, Jeong Ki Pack, Jeong-Sun Seo, Woong-Yang Park
摘要

Even though there is no direct evidence to prove the cellular and molecular changes induced by radiofrequency (RF) radiation itself, we cannot completely exclude the possibility of any biological effect of mobile phone frequency radiation. We established a carousel-type exposure chamber for 849 MHz or 1763 MHz of mobile phone RF radiation to expose RF to the heads of C57BL mice. In this chamber, animals were irradiated intermittently at 7.8 W/kg for a maximum of 12 months. During this period, the body weights of 3 groups-sham, 849 MHz RF, and 1763 MHz RF-did not show any differences between groups. The brain tissues were obtained from 3 groups at 6 months and 12 months to examine the differences in histology and cell proliferation between control and RF exposure groups, but we could not find any change upon RF radiation. Likewise, we could not find changes in the expression and distribution of NeuN and GFAP in hippocampus and cerebellum, or in cell death by TUNEL assay in RF exposure groups. From these data, we conclude that the chronic exposure to 849 MHz and 1763 MHz RF radiation at a 7.8 W/kg specific absorption rate (SAR) could not induce cellular alterations such as proliferation, death, and reactive gliosis.

材料
货号
品牌
产品描述

Sigma-Aldrich
抗NeuN抗体,克隆A60, clone A60, Chemicon®, from mouse
Sigma-Aldrich
抗神经胶质纤维酸性蛋白抗体,克隆GA5, ascites fluid, clone GA5, Chemicon®
Sigma-Aldrich
ApopTag Plus过氧化物酶原位凋亡检测试剂盒, The ApopTag Plus Peroxidase In Situ Apoptosis Detection Kit detects apoptotic cells by labeling & detecting DNA strand breaks by the indirect TUNEL method.
Sigma-Aldrich
ApopTag Positive Control Slides, rat mammary gland 4d post weaning, This product is intended as a positive control for use with all ApopTag In Situ Apoptosis Detection Kits.