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  • The neuropeptide calcitonin gene-related peptide (CGRP) stimulates T cell migration into collagen matrices.

The neuropeptide calcitonin gene-related peptide (CGRP) stimulates T cell migration into collagen matrices.

Journal of neuroimmunology (2008-04-22)
Toomas Talme, Zhiwen Liu, Karl-Gösta Sundqvist
摘要

CGRP significantly stimulated migration of non-activated and anti-CD3 activated T lymphocytes into a collagen matrix when present inside the collagen, whereas somatostatin-14, NPY, substance P, VIP, beta-endorphin and metenkephalin had no or little effect. The CGRP antagonist CGRP 8-37 abrogated the CGRP-induced cell infiltration. Virtually all migrating cells were CD3+ (>96%) and CGRP did not stimulate B-cell migration. The migration capacity showed no selective relationship to the expression of CD4+, CD8+, CD45RO+ (memory), or CD45RA+ (naive) T cell markers indicating that the regulation of T cell migration is distinct from that of the major T cell phenotypes.

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Sigma-Aldrich
CGRP II 8-37 human / β CGRP 8-37 human

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