• 主页
  • 查找结果
  • Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin.

Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin.

Journal of the American Chemical Society (2010-03-17)
Sarah D Brown, Paola Nativo, Jo-Ann Smith, David Stirling, Paul R Edwards, Balaji Venugopal, David J Flint, Jane A Plumb, Duncan Graham, Nial J Wheate
摘要

The platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin are an important component of chemotherapy but are limited by severe dose-limiting side effects and the ability of tumors to develop resistance rapidly. These drugs can be improved through the use of drug-delivery vehicles that are able to target cancers passively or actively. In this study, we have tethered the active component of the anticancer drug oxaliplatin to a gold nanoparticle for improved drug delivery. Naked gold nanoparticles were functionalized with a thiolated poly(ethylene glycol) (PEG) monolayer capped with a carboxylate group. [Pt(1R,2R-diaminocyclohexane)(H(2)O)(2)]2NO(3) was added to the PEG surface to yield a supramolecular complex with 280 (+/-20) drug molecules per nanoparticle. The platinum-tethered nanoparticles were examined for cytotoxicity, drug uptake, and localization in the A549 lung epithelial cancer cell line and the colon cancer cell lines HCT116, HCT15, HT29, and RKO. The platinum-tethered nanoparticles demonstrated as good as, or significantly better, cytotoxicity than oxaliplatin alone in all of the cell lines and an unusual ability to penetrate the nucleus in the lung cancer cells.

材料
货号
品牌
产品描述

Sigma-Aldrich
Gold nanoparticles, 50 nm diameter, OD 1, stabilized suspension in 0.1 mM PBS, reactant free
Sigma-Aldrich
Gold nanoparticles, 100 nm diameter, OD 1, stabilized suspension in 0.1 mM PBS, reactant free
Sigma-Aldrich
Gold nanoparticles, 15 nm diameter, amine functionalized, PEG 5000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 40 nm diameter, methyl terminated, PEG 5000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 15 nm diameter, OD 50, methyl terminated, PEG 5000 coated, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 20 nm diameter, carboxylic acid functionalized, PEG 3000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 20 nm diameter, methyl terminated, PEG 5000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 15 nm diameter, methyl terminated, PEG 2000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 50 nm diameter, methyl terminated, PEG 2000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 5 nm diameter, carboxylic acid functionalized, PEG 5000 coated, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 30 nm diameter, amine functionalized, PEG 5000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 5 nm diameter, amine functionalized, PEG 3000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 40 nm diameter, methyl terminated, PEG 2000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 30 nm diameter, methyl terminated, PEG 2000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 5 nm diameter, methyl terminated, PEG 2000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 5 nm diameter, methyl terminated, PEG 5000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 40 nm diameter, amine functionalized, PEG 3000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 40 nm diameter, amine functionalized, PEG 5000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 30 nm diameter, methyl terminated, PEG 5000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 10 nm diameter, methyl terminated, PEG 5000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 10 nm diameter, amine functionalized, PEG 5000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 50 nm diameter, methyl terminated, PEG 5000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 10 nm diameter, amine functionalized, PEG 3000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 20 nm diameter, amine functionalized, PEG 5000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 10 nm diameter, methyl terminated, PEG 2000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 30 nm diameter, amine functionalized, PEG 3000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 5 nm diameter, amine functionalized, PEG 5000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 20 nm diameter, amine functionalized, PEG 3000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 20 nm diameter, methyl terminated, PEG 2000 coated, OD 50, dispersion in H2O
Sigma-Aldrich
Gold nanoparticles, 15 nm diameter, amine functionalized, PEG 3000 coated, OD 50, dispersion in H2O

社交媒体

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

Merck

科研、开发、生产。

作为生命科学行业的全球领先供应商,我们致力于为科研、生物技术开发和生产,以及制药药物疗法开发和生产提供各类解决方案和服务。

© 2021年版权归德国达姆施塔特默克集团(Merck KGaA)及/或其附属公司所有。版权所有。

未经许可,严禁复制本网站上的任何资料。