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  • Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids.

Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids.

Bioorganic & medicinal chemistry (2010-05-11)
Marc Lamblin, Basel Dabbas, Russell Spingarn, Rodrigo Mendoza-Sanchez, Tian-Tian Wang, Beum-Soo An, Dao Chao Huang, Richard Kremer, John H White, James L Gleason
摘要

Incorporation of zinc-binding groups into the side-chain of 1alpha,25-dihydroxyvitamin D(3) (1,25D) fully bifunctional hybrid molecules which act both as vitamin D receptor agonists and histone deacetylase inhibitors. These bifunctional hybrids display in vitro antiproliferative activity against the AT84 squamous carcinoma cell line while lacking the in vivo hypercalcemic effects of 1,25D.

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产品描述

Sigma-Aldrich
1α,25-二羟基维生素D3, ≥99% (HPLC)
Sigma-Aldrich
1α,25-二羟基维生素D3, ≥97.0% (HPLC)
Sigma-Aldrich
1α,25-Dihydroxyvitamin D2 solution, 50 μg/mL in ethanol, 95% (CP)
Sigma-Aldrich
1α,25-Dihydroxyvitamin D2 solution, 100 μg/mL in ethanol, 95% (CP)