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Pulse-oximetry accurately predicts lung pathology and the immune response during influenza infection.

Virology (2009-06-06)
David Verhoeven, John R Teijaro, Donna L Farber
ABSTRACT

In animal models of influenza, systemic weight loss is the primary indicator of morbidity from infection, which does not assess local lung pathology or the immune response. Here, we used a mouse-adapted pulse-oximeter as a non-invasive clinical readout of lung function during influenza infection in mice, and found direct correlations between oxygen saturation levels and lung pathology, that reflected the morbidity and survival from influenza infection. We found blood oxygen levels to be a more accurate assessment than weight-loss morbidity in predicting lung pathology in hosts infected with different viral doses, and in assessing immune-mediated viral clearance in the lung.

MATERIALS
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Brand
Product Description

Sigma-Aldrich
牛血清白蛋白 来源于牛血清, heat shock fraction, protease free, fatty acid free, essentially globulin free, pH 7, ≥98%
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牛血清白蛋白 来源于牛血清, heat shock fraction, pH 7, ≥98%
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牛血清白蛋白 来源于牛血清, lyophilized powder, ≥96% (agarose gel electrophoresis)
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牛血清白蛋白 来源于牛血清, heat shock fraction, pH 7, ≥98%
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牛血清白蛋白 来源于牛血清, lyophilized powder, BioReagent, suitable for cell culture
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牛血清白蛋白 来源于牛血清, fatty acid free, low endotoxin, lyophilized powder, BioReagent, suitable for cell culture, ≥96% (agarose gel electrophoresis)
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牛血清白蛋白 来源于牛血清, heat shock fraction, protease free, essentially globulin free, pH 7, ≥98%
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牛血清白蛋白 来源于牛血清, heat shock fraction, protease free, pH 7, ≥98%
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牛血清白蛋白 来源于牛血清, lyophilized powder, essentially fatty acid free, ≥96% (agarose gel electrophoresis)
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牛血清白蛋白 来源于牛血清, lyophilized powder, suitable for (for molecular biology), Non-acetylated
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牛血清白蛋白 来源于牛血清, heat shock fraction, suitable for RIA, pH 5.2, ≥96%
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牛血清白蛋白 来源于牛血清, heat shock fraction, lyophilized powder, essentially fatty acid free, ≥98% (agarose gel electrophoresis)
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牛血清白蛋白 来源于牛血清, lyophilized powder, essentially globulin free, ≥99% (agarose gel electrophoresis)
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牛血清白蛋白 来源于牛血清, heat shock fraction, pH 5.2, ≥96%
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牛血清白蛋白 来源于牛血清, powder, BioXtra
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牛血清白蛋白 来源于牛血清, heat shock fraction, protease free, suitable for hybridization, pH 7, ≥98%
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牛血清白蛋白 来源于牛血清, lyophilized powder, crystallized, ≥98.0% (GE)
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牛血清白蛋白 来源于牛血清, lyophilized powder, essentially IgG-free, low endotoxin, BioReagent, suitable for cell culture
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牛血清白蛋白 来源于牛血清, heat shock fraction, pH 5.2, ≥96%
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牛血清白蛋白 来源于牛血清, lyophilized powder, 1× crystallized, ≥97% (agarose gel electrophoresis)
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牛血清白蛋白 来源于牛血清, heat shock fraction, protease free, low endotoxin, suitable for cell culture, pH 7, ≥98%
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牛血清白蛋白 来源于牛血清, lyophilized powder, essentially IgG free, ≥96% (agarose gel electrophoresis)
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牛血清白蛋白 来源于牛血清, lyophilized powder, essentially globulin free, BioReagent, suitable for cell culture
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牛血清白蛋白 来源于牛血清, lyophilized powder, essentially globulin free, low endotoxin, ≥98% (agarose gel electrophoresis)