Merck

Glucose-6-phosphate dehydrogenase, NADPH, and cell survival.

IUBMB life (2012-03-21)
Robert C Stanton
摘要

Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway. Many scientists think that the roles and regulation of G6PD in physiology and pathophysiology have been well established as the enzyme was first identified 80 years ago. And that G6PD has been extensively studied especially with respect to G6PD deficiency and its association with hemolysis, and with respect to the role G6PD plays in lipid metabolism. But there has been a growing understanding of the central importance of G6PD to cellular physiology as it is a major source of NADPH that is required by many essential cellular systems including the antioxidant pathways, nitric oxide synthase, NADPH oxidase, cytochrome p450 system, and others. Indeed G6PD is essential for cell survival. It has also become evident that G6PD is highly regulated by many signals that affect transcription, post-translation, intracellular location, and interactions with other protein. Pathophysiologic roles for G6PD have also been identified in such disease processes as diabetes, aldosterone-induced endothelial dysfunction, cancer, and others. It is now clear that G6PD is under complex regulatory control and of central importance to many cellular processes. In this review the biochemistry, regulatory signals, physiologic roles, and pathophysiologic roles for G6PD that have been elucidated over the past 20 years are discussed.

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Sigma-Aldrich
葡萄糖-6-磷酸脱氢酶 来源于面包酵母(酿酒酵母), Type XV, lyophilized powder, 200-400 units/mg protein (modified Warburg-Christian)
Sigma-Aldrich
葡萄糖-6-磷酸脱氢酶 来源于面包酵母(酿酒酵母), Type VII, ammonium sulfate suspension, ≥200 units/mg protein
Sigma-Aldrich
葡萄糖-6-磷酸脱氢酶 来源于肠系膜明串珠菌, lyophilized powder, >= 550 units/mg protein (biuret)
Sigma-Aldrich
葡萄糖-6-磷酸脱氢酶 来源于肠系膜明串珠菌, recombinant, expressed in E. coli, ammonium sulfate suspension, ≥550 units/mg protein (biuret)
Sigma-Aldrich
葡萄糖-6-磷酸脱氢酶 来源于面包酵母(酿酒酵母), Type IX, lyophilized powder, 200-400 units/mg protein (modified Warburg-Christian)
Roche
己糖激酶/葡萄糖-6-磷酸脱氢酶(HK / G6P-DH), from yeast/Leuconostoc, overproducer
Sigma-Aldrich
葡萄糖-6-磷酸脱氢酶 来源于肠系膜明串珠菌, recombinant, expressed in E. coli, lyophilized powder, ≥550 units/mg protein (biuret)
Sigma-Aldrich
葡萄糖-6-磷酸脱氢酶 来源于肠系膜明串珠菌, Type XXIII, ammonium sulfate suspension, 550-1,100 units/mg protein (biuret), ≥2.0 mg/mL Biuret
Sigma-Aldrich
高灵敏度葡萄糖-6-磷酸检测试剂盒, sufficient for 100 fluorometric tests
Sigma-Aldrich
G6PD from E. coli, recombinant, expressed in E. coli, ≥90% (SDS-PAGE)