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  • Rickets caused by excessive renal phosphate loss and apparent abnormal vitamin D metabolism in a cat.

Rickets caused by excessive renal phosphate loss and apparent abnormal vitamin D metabolism in a cat.

Journal of the American Veterinary Medical Association (2003-10-22)
R A Henik, L J Forrest, A L Friedman
摘要

Rickets was diagnosed in a 1-year-old cat with a history of weakness, osteopenia, and recurrent fractures. Processes causing rickets include vitamin D deficiency caused by inadequate, nutrition, lack of exposure to sunlight, defective metabolism of parent vitamin D to active metabolites, inherited vitamin D receptor defects, hypoparathyroidism, chronic renal failure, renal loss of phosphate, or malabsorptive states resulting from gastrointestinal or hepatic diseases. On the basis of analysis of serum 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D2 and D3 concentrations, serum biochemical analysis, and urinary fractional clearance of electrolytes, the causes of rickets in our cat, were most compatible with a combination of excessive loss of phosphorus via the kidneys and deficient or abnormal hepatic 25-hydroxylation of vitamin D. Calcifediol treatment and twice daily administration of phosphate salts resulted in clinical improvement and increases in mineralization of the skeleton, as evidenced on radiographic evaluation.

材料
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品牌
产品描述

Supelco
1α,25-二羟基维生素D2标准液 溶液, 5 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®
Sigma-Aldrich
1α,25-二羟维生素 D2, ≥97.0% (sum of vitamin and previtamin, HPLC)