Merck
  • Home
  • Search Results
  • Synthesis of sterically congested 1,3,4-oxadiazole derivatives from aromatic carboxylic acids, N,N-dicyclohexylcarbodiimide and (N-isocyanimino)triphenylphosphorane.

Synthesis of sterically congested 1,3,4-oxadiazole derivatives from aromatic carboxylic acids, N,N-dicyclohexylcarbodiimide and (N-isocyanimino)triphenylphosphorane.

Molecular diversity (2011-03-23)
Fatemeh Zeinali Nasrabadi, Ali Ramazani, Yavar Ahmadi
ABSTRACT

Reactions of (N-isocyanimino)triphenylphosphorane with N,N-dicyclohexylcarbodiimide in the presence of aromatic (or heteroaromatic) carboxylic acids proceed smoothly at room temperature and in neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in high yields. The reaction proceeds smoothly and cleanly under mild conditions, and no side reactions were observed.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
N,N′-二环己基碳二亚胺, 99%
Sigma-Aldrich
N,N′-二环己基碳二亚胺, puriss., ≥99.0% (GC)
Sigma-Aldrich
N,N′-二环己基碳二亚胺 溶液, 1.0 M in methylene chloride
Sigma-Aldrich
二环己基碳二亚胺 溶液, 60 wt. % in xylenes