• 主页
  • 查找结果
  • Click-to-Chelate: development of technetium and rhenium-tricarbonyl labeled radiopharmaceuticals.

Click-to-Chelate: development of technetium and rhenium-tricarbonyl labeled radiopharmaceuticals.

Molecules (Basel, Switzerland) (2013-03-14)
Christiane A Kluba, Thomas L Mindt
摘要

The Click-to-Chelate approach is a highly efficient strategy for the radiolabeling of molecules of medicinal interest with technetium and rhenium-tricarbonyl cores. Reaction of azide-functionalized molecules with alkyne prochelators by the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC; click reaction) enables the simultaneous synthesis and conjugation of tridentate chelating systems for the stable complexation of the radiometals. In many cases, the functionalization of (bio)molecules with the ligand system and radiolabeling can be achieved by convenient one-pot procedures. Since its first report in 2006, Click-to-Chelate has been applied to the development of numerous novel radiotracers with promising potential for translation into the clinic. This review summarizes the use of the Click-to-Chelate approach in radiopharmaceutical sciences and provides a perspective for future applications.

材料
货号
品牌
产品描述

Sigma-Aldrich
铼, powder, 99.995% trace metals basis
Sigma-Aldrich
铼, foil, thickness 0.25 mm, 99.98% trace metals basis
Sigma-Aldrich
铼, powder, −100 mesh, ≥99.9% trace metals basis
铼, wire reel, 0.025m, diameter 1.0mm, annealed, 99.97%
铼, wire reel, 0.05m, diameter 0.5mm, annealed, 99.97%
铼, wire reel, 0.05m, diameter 1.0mm, annealed, 99.97%
铼, wire reel, 0.1m, diameter 0.076mm, annealed, 99.97%
铼, wire reel, 0.1m, diameter 0.10mm, annealed, 99.97%
铼, wire reel, 0.1m, diameter 0.125mm, annealed, 99.97%
铼, wire reel, 0.1m, diameter 0.15mm, annealed, 99.97%
铼, wire reel, 0.1m, diameter 0.178mm, annealed, 99.97%
铼, wire reel, 0.1m, diameter 0.25mm, annealed, 99.97%
铼, wire reel, 0.1m, diameter 0.2mm, annealed, 99.97%
铼, wire reel, 0.1m, diameter 0.3mm, annealed, 99.97%
铼, wire reel, 0.1m, diameter 0.5mm, annealed, 99.97%
铼, wire reel, 0.1m, diameter 1.0mm, annealed, 99.97%
铼, wire reel, 0.2m, diameter 0.076mm, annealed, 99.97%
铼, wire reel, 0.2m, diameter 0.10mm, annealed, 99.97%
铼, wire reel, 0.2m, diameter 0.125mm, annealed, 99.97%
铼, wire reel, 0.2m, diameter 0.15mm, annealed, 99.97%
铼, wire reel, 0.2m, diameter 0.178mm, annealed, 99.97%
铼, wire reel, 0.2m, diameter 0.25mm, annealed, 99.97%
铼, wire reel, 0.2m, diameter 0.2mm, annealed, 99.97%
铼, wire reel, 0.2m, diameter 0.3mm, annealed, 99.97%
铼, wire reel, 0.2m, diameter 0.5mm, annealed, 99.97%
铼, wire reel, 0.2m, diameter 1.0mm, annealed, 99.97%
铼, wire reel, 0.5m, diameter 0.076mm, annealed, 99.97%
铼, wire reel, 0.5m, diameter 0.10mm, annealed, 99.97%
铼, wire reel, 0.5m, diameter 0.125mm, annealed, 99.97%
铼, wire reel, 0.5m, diameter 0.15mm, annealed, 99.97%

社交媒体

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

Merck

科研、开发、生产。

作为生命科学行业的全球领先供应商,我们致力于为科研、生物技术开发和生产,以及制药药物疗法开发和生产提供各类解决方案和服务。

© 2021年版权归德国达姆施塔特默克集团(Merck KGaA)及/或其附属公司所有。版权所有。

未经许可,严禁复制本网站上的任何资料。