Reversal of malignancy by the adenovirus E1a gene.

Mutation research (1996-02-19)
S M Frisch
摘要

Tumor suppressor genes such as Rb and p53 usually kill tumor cells when overexpressed ectopically. This is a consequence of their normal cell cycle regulatory functions. By contrast, the E1a gene of adenovirus, a common cold virus, converts tumor cells into viable normal cells. This has advantages for investigation and control of cancer. In particular, E1a is a master programmer of the epithelial phenotype. This provides a new tool for understanding the molecular basis of the epithelial-mesenchymal transition, and how it goes awry in cancer cells. Furthermore, epithelial cells are sensitive to a form of apoptosis - 'anoikis' - that is induced by detachment from extracellular matrix. This property confers strict anchorage-dependence. Transcriptional programming, by E1a or the formation of cell-cell junctional complexes, programs epithelial cells to be sensitive to anoikis.

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产品描述

Sigma-Aldrich
Anti-E1A (Adenovirus Early Region 1A) antibody produced in sheep, fractionated antiserum
Sigma-Aldrich
Monoclonal Anti-Adenovirus 2 E1A (Adenovirus 2 early region 1) antibody produced in mouse, 1.0 mg/mL, clone M73, purified immunoglobulin, buffered aqueous solution

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