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  • Eunicellin-based diterpenoids from the Formosan soft coral Klyxum molle with inhibitory activity on superoxide generation and elastase release by neutrophils.

Eunicellin-based diterpenoids from the Formosan soft coral Klyxum molle with inhibitory activity on superoxide generation and elastase release by neutrophils.

Journal of natural products (2013-09-12)
Ming-Chang Lin, Bo-Wei Chen, Chiung-Yao Huang, Chang-Feng Dai, Tsong-Long Hwang, Jyh-Horng Sheu
摘要

Eleven new eunicellin-based diterpenoids possessing a cladiellane skeleton with a C-2, C-9 ether bridge, klymollins I-S (1-11), have been isolated from the EtOAc extract of the soft coral Klyxum molle from Taiwan waters. The structures of compounds 1-11 were elucidated by extensive spectroscopic analysis, including 2D NMR spectroscopy (COSY, HSQC, HMBC, and NOESY). Compound 5 exhibited cytotoxicity toward several cancer cell lines. Compound 5 is the first eunicellin-based metabolite bearing a phenyl group and displays significant inhibition of both superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced human neutrophils.

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Sigma-Aldrich
细胞松弛素B 来源于Drechslera dematioidea, ≥98% (HPLC), powder
Sigma-Aldrich
弹性蛋白酶 来源于猪胰腺, Type I, ≥4.0 units/mg protein
Sigma-Aldrich
弹性蛋白酶 来源于猪胰腺, lyophilized powder, suitable for cell culture
Sigma-Aldrich
N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸, ≥97% (HPLC)
Sigma-Aldrich
细胞松弛素B 来源于Drechslera dematioidea, Ready Made Solution, 10 mg/mL in DMSO
Sigma-Aldrich
弹性蛋白酶 来源于猪胰腺, Type IV, Protein 50-90 %, lyophilized powder, ≥4.0 units/mg protein (biuret)
Sigma-Aldrich
弹性蛋白酶 来源于猪胰腺, Type III, lyophilized powder, Protein 55-85 %, ≥4.0 units/mg protein
Sigma-Aldrich
N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸, BioXtra, ≥99.0% (TLC)