Merck

Cell biology of molybdenum in plants and humans.

Biochimica et biophysica acta (2012-03-01)
Ralf R Mendel, Tobias Kruse
摘要

The transition element molybdenum (Mo) needs to be complexed by a special cofactor in order to gain catalytic activity. With the exception of bacterial Mo-nitrogenase, where Mo is a constituent of the FeMo-cofactor, Mo is bound to a pterin, thus forming the molybdenum cofactor Moco, which in different variants is the active compound at the catalytic site of all other Mo-containing enzymes. In eukaryotes, the most prominent Mo-enzymes are nitrate reductase, sulfite oxidase, xanthine dehydrogenase, aldehyde oxidase, and the mitochondrial amidoxime reductase. The biosynthesis of Moco involves the complex interaction of six proteins and is a process of four steps, which also requires iron, ATP and copper. After its synthesis, Moco is distributed to the apoproteins of Mo-enzymes by Moco-carrier/binding proteins. A deficiency in the biosynthesis of Moco has lethal consequences for the respective organisms. In humans, Moco deficiency is a severe inherited inborn error in metabolism resulting in severe neurodegeneration in newborns and causing early childhood death. This article is part of a Special Issue entitled: Cell Biology of Metals.

材料
货号
品牌
产品描述

Sigma-Aldrich
钼, powder, <150 μm, 99.9% trace metals basis
Sigma-Aldrich
钼, powder, 1-5 μm, ≥99.9% trace metals basis
Sigma-Aldrich
钼, foil, thickness 0.025 mm, ≥99.9% trace metals basis
Sigma-Aldrich
钼, powder, <150 μm, 99.99% trace metals basis
Sigma-Aldrich
钼, foil, thickness 0.1 mm, ≥99.9% trace metals basis
Sigma-Aldrich
钼, wire, diam. 1.0 mm, 99.95% trace metals basis
Sigma-Aldrich
钼, powder, 10 μm, ≥99.95% trace metals basis
Sigma-Aldrich
钼, nanopowder, <100 nm particle size (TEM), 99.8% trace metals basis
Sigma-Aldrich
钼, foil, thickness 1.0 mm, ≥99.9% trace metals basis
钼, rod, 1000mm, diameter 3.0mm, centerless ground, 99.9%
钼, rod, 50mm, diameter 5.0mm, 99.98%
钼, pellets, 100g, max. size 10mm, 99.9%
钼, pellets, 200g, max. size 10mm, 99.9%
钼, mesh, 100x100mm, nominal aperture 0.44mm, wire diameter 0.07mm, 50 wires/inch, open area 67%, plain weave mesh
钼, rod, 150mm, diameter 5.0mm, 99.98%
钼, foil, 50x50mm, thickness 0.1mm, annealed, 99.9%
钼, foil, 1m coil, thickness 0.01mm, 99.9%
钼, foil, 300x300mm, thickness 0.25mm, annealed, 99.9%
钼, foil, 100x100mm, thickness 0.30mm, annealed, 99.9%
钼, wire, straight, 1000mm, diameter 0.25mm, 99.95%
钼, rod, 100mm, diameter 5.0mm, 99.98%
钼, foil, not light tested, 25x25mm, thickness 0.001mm, 99.9%
钼, foil, not light tested, 50x50mm, thickness 0.001mm, 99.9%
钼, foil, 4mm disks, thickness 0.01mm, 99.9%
钼, foil, 8mm disks, thickness 0.007mm, 99.9%
钼, foil, 100x100mm, thickness 0.5mm, annealed, 99.9%
钼, foil, 6mm disks, thickness 0.008mm, 99.9%
钼, pellets, 50g, max. size 10mm, 99.9%
钼, wire reel, 5m, diameter 0.025mm, gold plated, 99.95%
钼, foil, 25x25mm, thickness 0.125mm, annealed, 99.9%