Mechanistic studies on the reactions of platinum(II) complexes with nitrogen- and sulfur-donor biomolecules.

Mechanistic studies on the reactions of platinum(II) complexes with nitrogen- and sulfur-donor biomolecules.

Dalton transactions (Cambridge, England : 2003) (2012-08-15)

Živadin D Bugarčić, Jovana Bogojeski, Biljana Petrović, Stephanie Hochreuther, Rudi van Eldik

ABSTRACT

A brief overview of mechanistic studies on the reactions of different Pt(II) complexes with nitrogen- and sulfur-donor biomolecules is presented. The first part describes the results obtained for substitution reactions of mono-functional Pt(II) complexes with different biomolecules, under various experimental conditions (temperature, pH and ionic strength). In addition, an overview of the results obtained for the substitution reactions of bi-functional Pt(II) complexes, analogous to cisplatin, with biomolecules is given. The last part of this report deals with different polynuclear Pt(II) complexes and their substitution behaviour with different biomolecules. The purpose of this perspective is to improve the understanding of the mechanism of action of Pt(II) complexes as potential anti-tumour drugs in the human body.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

硫, powder, 99.98% trace metals basis

Sigma-Aldrich

硫, 99.998% trace metals basis

Sigma-Aldrich

铂, wire, diam. 0.5 mm, 99.99% trace metals basis

Sigma-Aldrich

铂, wire, diam. 0.5 mm, 99.9% trace metals basis

Sigma-Aldrich

铂黑, black, powder, ≤20 μm, ≥99.95% trace metals basis

Sigma-Aldrich

铂, wire, diam. 1.0 mm, 99.9% trace metals basis

Sigma-Aldrich

铂, foil, thickness 0.025 mm, 99.9% trace metals basis

Sigma-Aldrich

铂, wire, diam. 0.25 mm, 99.9% trace metals basis

Supelco

硫, PESTANAL^®, analytical standard

Sigma-Aldrich

铂, gauze, 100 mesh, 99.9% trace metals basis

Sigma-Aldrich

铂, powder, 99.995% trace metals basis

Sigma-Aldrich

硫, flakes, ≥99.99% trace metals basis

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铂, wire, diam. 2.0 mm, 99.9% trace metals basis

Sigma-Aldrich

铂, nanopowder, <50 nm particle size (TEM)

Sigma-Aldrich

铂, foil, thickness 0.05 mm, 99.99% trace metals basis

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铂, gauze, 52 mesh, 99.9% trace metals basis

Sigma-Aldrich

铂, wire, diam. 0.25 mm, 99.99% trace metals basis

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铂, wire, diam. 0.076 mm, ≥99.99% trace metals basis

Sigma-Aldrich

铂, powder (coarse), 99.99% trace metals basis

Sigma-Aldrich

铂, wire, diam. 0.25 mm, thermocouple grade

Sigma-Aldrich

铂黑, fuel cell grade, ≥99.9% trace metals basis

Sigma-Aldrich

铂, foil, thickness 0.1 mm, 99.9% trace metals basis

Sigma-Aldrich

铂, nanopowder, 200 nm particle size (SEM), 99.9% (metals basis)

Sigma-Aldrich

铂, wire, diam. 0.10 mm, 99.99% trace metals basis

Sigma-Aldrich

铂, foil, thickness 1.0 mm, 99.99% trace metals basis

铂, wire reel, 1m, diameter 0.5mm, as drawn, 99.99+%

铂, rod, 25mm, diameter 3.0mm, 99.95%

铂, foil, 50x50mm, thickness 0.1mm, as rolled, 99.95%

Sigma-Aldrich

铂, wire, diam. 0.20 mm, ≥99.99% trace metals basis

铂, wire reel, 0.2m, diameter 0.8mm, annealed, may be used as one component of a thermocouple, 99.99%