Targeting and delivery of platinum-based anticancer drugs.

Chemical Society reviews (2012-10-09)
Xiaoyong Wang, Zijian Guo
摘要

Platinum-based anticancer drugs occupy a crucial role in the treatment of various malignant tumours. However, the efficacy and applicability of platinum drugs are heavily restricted by severe systemic toxicities and drug resistance. Different drug targeting and delivery (DTD) strategies have been developed to prevent the shortcomings of platinum-based chemotherapy. These approaches can be roughly categorized into two groups; namely, active and passive tactics. Active DTD is realized through specific molecular interactions between the drugs and cell or tissue elements, while passive DTD is achieved by exploiting the enhanced permeability and retention effect in tumour tissues. The principal methods for active DTD include conjugation of platinum drugs with selective targeting moieties or encapsulation of platinum drugs in host molecules. Bioactive substances such as hormones, carbohydrates, bisphosphonates, peptides and proteins are commonly used in active DTD. Passive DTD generally involves the fabrication of functionalized polymers or nanoparticles and the subsequent conjugation of platinum drugs with such entities. Polymeric micelles, liposomes, nanotubes and nanoparticles are frequently used in passive DTD. In some cases, both active and passive mechanisms are involved in one DTD system. This review concentrates on various targeting and delivery techniques for improving the efficacy and reducing the side effects of platinum-based anticancer drugs. The content covers most of the related literatures published since 2006. These innovative tactics represent current state-of-the-art developments in platinum-based anticancer drugs.

材料
货号
品牌
产品描述

Sigma-Aldrich
铂, wire, diam. 0.5 mm, 99.99% trace metals basis
Sigma-Aldrich
铂, foil, thickness 0.025 mm, 99.9% trace metals basis
Sigma-Aldrich
铂, wire, diam. 0.25 mm, 99.9% trace metals basis
Sigma-Aldrich
铂, wire, diam. 0.5 mm, 99.9% trace metals basis
Sigma-Aldrich
铂, gauze, 100 mesh, 99.9% trace metals basis
Sigma-Aldrich
铂黑, black, powder, ≤20 μm, ≥99.95% trace metals basis
Sigma-Aldrich
铂, wire, diam. 1.0 mm, 99.9% trace metals basis
Sigma-Aldrich
铂, foil, thickness 0.05 mm, 99.99% trace metals basis
Sigma-Aldrich
铂, powder, 99.995% trace metals basis
Sigma-Aldrich
铂, gauze, 52 mesh, 99.9% trace metals basis
Sigma-Aldrich
铂, nanopowder, <50 nm particle size (TEM)
Sigma-Aldrich
铂, wire, diam. 2.0 mm, 99.9% trace metals basis
Sigma-Aldrich
铂, wire, diam. 0.10 mm, 99.99% trace metals basis
Sigma-Aldrich
铂, powder, ≤10 μm, 99.9% trace metals basis
Sigma-Aldrich
铂, wire, diam. 0.25 mm, 99.99% trace metals basis
Sigma-Aldrich
铂黑, fuel cell grade, ≥99.9% trace metals basis
Sigma-Aldrich
铂, wire, diam. 0.076 mm, ≥99.99% trace metals basis
Sigma-Aldrich
铂, foil, thickness 0.125-0.135 mm, 99.9% trace metals basis
Sigma-Aldrich
铂, foil, thickness 1.0 mm, 99.99% trace metals basis
Sigma-Aldrich
铂, foil, thickness 0.25 mm, 99.99% trace metals basis
Sigma-Aldrich
铂, nanopowder, 200 nm particle size (SEM), 99.9% (metals basis)
Sigma-Aldrich
铂, wire, diam. 0.25 mm, thermocouple grade
Sigma-Aldrich
铂, wire, diam. 0.127 mm, 99.99% trace metals basis
Sigma-Aldrich
铂, wire, diam. 1.0 mm, 99.99% trace metals basis
Sigma-Aldrich
铂, wire, diam. 0.20 mm, ≥99.99% trace metals basis
Sigma-Aldrich
铂, wire, diam. 0.127 mm, 99.9% trace metals basis
Sigma-Aldrich
铂, powder (coarse), 99.99% trace metals basis
Sigma-Aldrich
铂黑, low bulk density, ≥99.9% trace metals basis
铂, wire reel, 0.1m, diameter 1.0mm, annealed, may be used as one component of a thermocouple, 99.99%
铂, wire reel, 1m, diameter 0.3mm, annealed, may be used as one component of a thermocouple, 99.99%

社交媒体

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

Merck

科研、开发、生产。

作为生命科学行业的全球领先供应商,我们致力于为科研、生物技术开发和生产,以及制药药物疗法开发和生产提供各类解决方案和服务。

© 2021年版权归德国达姆施塔特默克集团(Merck KGaA)及/或其附属公司所有。版权所有。

未经许可,严禁复制本网站上的任何资料。