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Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?

Cardiovascular research (2013-02-19)
John Pernow, Christian Jung
ABSTRACT

Functional integrity of the vascular endothelium is of fundamental importance for normal vascular function. A key factor regulating endothelial function is the bioavailability of nitric oxide (NO). Recently, the enzyme arginase has emerged as an important regulator of NO production by competing for l-arginine, which is a substrate for both arginase and NO synthase. Increased activity of arginase may reduce the availability of l-arginine for NO synthase, thus reducing NO production, increasing formation of reactive oxygen species, and leading ultimately to endothelial dysfunction. Increased activity and expression of arginase have been demonstrated in several pathological cardiovascular conditions, including hypertension, pulmonary arterial hypertension, atherosclerosis, myocardial ischaemia, congestive heart failure, and vascular dysfunction in diabetes mellitus. Experimental studies have demonstrated that inhibition of arginase under these conditions increases NO bioavailability, reduces oxidative stress, improves vascular function, and protects against ischaemia-reperfusion injury. Initial clinical interventional studies are also promising. The purpose of this review is to discuss the role of arginase in cardiovascular pathologies, its contribution to the development of several cardiovascular disease states and the feasibility of using arginase inhibition as a therapeutic strategy.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
L-精氨酸, reagent grade, ≥98%
Sigma-Aldrich
L-精氨酸, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%
SAFC
L-精氨酸
Sigma-Aldrich
L-精氨酸, 99%, FCC, FG
Supelco
L-精氨酸, Pharmaceutical Secondary Standard; Certified Reference Material
精氨酸, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
L-精氨酸, BioUltra, ≥99.5% (NT)