• 主页
  • 查找结果
  • Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans.

Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans.

Critical reviews in toxicology (2013-03-01)
Chad M Thompson, Deborah M Proctor, Mina Suh, Laurie C Haws, Christopher R Kirman, Mark A Harris
摘要

Abstract Chronic exposure to high concentrations of hexavalent chromium (Cr(VI)) in drinking water causes intestinal adenomas and carcinomas in mice, but not in rats. Cr(VI) causes damage to intestinal villi and crypt hyperplasia in mice after only one week of exposure. After two years of exposure, intestinal damage and crypt hyperplasia are evident in mice (but not rats), as are intestinal tumors. Although Cr(VI) has genotoxic properties, these findings suggest that intestinal tumors in mice arise as a result of chronic mucosal injury. To better understand the mode of action (MOA) of Cr(VI) in the intestine, a 90-day drinking water study was conducted to collect histological, biochemical, toxicogenomic and pharmacokinetic data in intestinal tissues. Using MOA analyses and human relevance frameworks proposed by national and international regulatory agencies, the weight of evidence supports a cytotoxic MOA with the following key events: (a) absorption of Cr(VI) from the intestinal lumen, (b) toxicity to intestinal villi, (c) crypt regenerative hyperplasia and (d) clonal expansion of mutations within the crypt stem cells, resulting in late onset tumorigenesis. This article summarizes the data supporting each key event in the MOA, as well as data that argue against a mutagenic MOA for Cr(VI)-induced intestinal tumors.

材料
货号
品牌
产品描述

Sigma-Aldrich
铬, chips, 99.995% trace metals basis
Sigma-Aldrich
铬, powder, ≥99% trace metals basis, <45 μm
Sigma-Aldrich
铬, powder, 99.5%, −100 mesh
Sigma-Aldrich
铬, chips, thickness ~2 mm, 99.5%
铬, foil, light tested, 25x25mm, thickness 0.05mm, permanent polyester support, 99.99+%
铬, foil, light tested, 25x25mm, thickness 0.075mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 100x100mm, thickness 0.0125mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 100x100mm, thickness 0.015mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 100x100mm, thickness 0.01mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 100x100mm, thickness 0.025mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 100x100mm, thickness 0.02mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 100x100mm, thickness 0.03mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 100x100mm, thickness 0.04mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 25x25mm, thickness 0.0015mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 25x25mm, thickness 0.001mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 25x25mm, thickness 0.0025mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 25x25mm, thickness 0.002mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 25x25mm, thickness 0.003mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 25x25mm, thickness 0.004mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 25x25mm, thickness 0.005mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 25x25mm, thickness 0.007mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 25x25mm, thickness 0.009mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 25x25mm, thickness 0.0125mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 25x25mm, thickness 0.015mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 25x25mm, thickness 0.01mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 25x25mm, thickness 0.025mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 25x25mm, thickness 0.03mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 25x25mm, thickness 0.04mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 25x25mm, thickness 0.05mm, permanent polyester support, 99.99+%
铬, foil, not light tested, 25x25mm, thickness 0.075mm, permanent polyester support, 99.99+%

社交媒体

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

Merck

科研、开发、生产。

作为生命科学行业的全球领先供应商,我们致力于为科研、生物技术开发和生产,以及制药药物疗法开发和生产提供各类解决方案和服务。

© 2021年版权归德国达姆施塔特默克集团(Merck KGaA)及/或其附属公司所有。版权所有。

未经许可,严禁复制本网站上的任何资料。