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  • Using the hemoglobin content of reticulocytes (RET-He) to evaluate anemia in patients with cancer.

Using the hemoglobin content of reticulocytes (RET-He) to evaluate anemia in patients with cancer.

American journal of clinical pathology (2014-09-23)
Ellinor I B Peerschke, Melissa S Pessin, Peter Maslak
摘要

Evaluation of anemia, particularly iron deficiency, in patients with cancer is difficult. This study examined using the hemoglobin content of reticulocytes (RET-He) to rule out iron deficiency, as defined by serum iron studies (transferrin saturation <20%, serum iron <40 μg/dL, and ferritin <100 ng/mL), in an unselected cancer patient population. Patients were entered into the study based on the existence of concurrent laboratory test requests for CBC and serum iron studies. Using a threshold of 32 pg/cell, RET-He ruled out iron deficiency with a negative predictive value (NPV) of 98.5% and 100%, respectively, in the study population (n = 209) and in a subpopulation of patients with low reticulocyte counts (n = 19). In comparison, the NPV of traditional CBC parameters (hemoglobin, <11 g/dL; mean corpuscular volume, <80 fL) was only 88.5%. These results support the use of RET-He in the evaluation of iron deficiency in a cancer care setting.

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铁, ≥99%, reduced, powder (fine)
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铁蛋白 来源于马脾脏, Type I, saline solution
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羰基铁, ≥97% Fe basis
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铁, puriss. p.a., carbonyl-Iron powder, low in magnesium and manganese compounds, ≥99.5% (RT)
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铁, flakes, ≥99.99% trace metals basis
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铁, nanopowder, 35-45 nm particle size, 99.5% trace metals basis
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铁, granular, 10-40 mesh, >99.99% trace metals basis
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铁, chips, 99.98% trace metals basis
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铁, foil, thickness 0.1 mm, ≥99.9% trace metals basis
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铁蛋白 来源于人类肝脏, Type IV, 10 μg/mL
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铁, foil, thickness 0.25 mm, ≥99.99% trace metals basis
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铁蛋白 来源于人类脾脏, Type V, 10 μg/mL in 0.15 M NaCl, 10 mM Tris, pH 8.0, containing 0.1% sodium azide
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铁, wire, diam. 1.0 mm, ≥99.9% trace metals basis
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铁, carbon coated magnetic, nanopowder, 25 nm avg. part. size, 99.5% trace metals basis
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铁, wire, diam. 0.5 mm, ≥99.9% trace metals basis
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铁, rod, diam. 6.3 mm, 99.98% trace metals basis
铁, IRMM®, certified reference material, 0.5 mm wire
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铁, wire reel, 20m, diameter 0.125mm, hard, 99.5%
铁, foil, 10mm disks, thickness 0.01mm, 99.85%
铁, foil, 10mm disks, thickness 0.01mm, 99.99+%
铁, foil, 10mm disks, thickness 0.020mm, 99.85%
铁, foil, 10mm disks, thickness 0.025mm, as rolled, 99.99+%
铁, foil, 10mm disks, thickness 0.025mm, hard, 99.5%
铁, foil, 10mm disks, thickness 0.038mm, hard, 99.5%
铁, foil, 10mm disks, thickness 0.05mm, as rolled, 99.99+%

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