Merck
  • Home
  • Search Results
  • Idebenone loaded solid lipid nanoparticles: calorimetric studies on surfactant and drug loading effects.

Idebenone loaded solid lipid nanoparticles: calorimetric studies on surfactant and drug loading effects.

International journal of pharmaceutics (2014-05-23)
Maria Grazia Sarpietro, Maria Lorena Accolla, Giovanni Puglisi, Francesco Castelli, Lucia Montenegro
ABSTRACT

In this study we prepared solid lipid nanoparticles (SLN), by the phase inversion temperature (PIT) method, using cetyl palmitate as solid lipid and three different non-ionic emulsifiers of the polyoxyethylene ethers family (ceteth-20, isoceteth-20, oleth-20). These SLN were loaded with different amount of idebenone (IDE), an antioxidant drug useful in the treatment of neurodegenerative diseases and skin oxidative damages. The differential scanning calorimetry (DSC) was employed to evaluate the effects of the different emulsifiers and the different amounts of drug loaded on the thermotropic behavior of SLN and to investigate how the drug was arranged into these nanoparticles. The IDE seemed to be located into different regions of the SLN depending on its concentration and on the surfactant used. The results of this study suggest that the calorimetric studies performed on SLN could provide valuable information to optimize SLN design and drug release from these carriers.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
二乙醚, contains 1 ppm BHT as inhibitor, anhydrous, ≥99.7%
Sigma-Aldrich
二乙醚, anhydrous, ACS reagent, ≥99.0%, contains BHT as inhibitor
Sigma-Aldrich
二乙醚, suitable for HPLC, ≥99.9%, inhibitor-free
Sigma-Aldrich
二乙醚, ACS reagent, anhydrous, ≥99.0%, contains BHT as inhibitor
Sigma-Aldrich
二乙醚, contains BHT as inhibitor, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.8%
Sigma-Aldrich
氧氯化锆 八水合物, reagent grade, 98%
Sigma-Aldrich
二乙醚, ACS reagent, ≥98.0%, contains ≤2% ethanol and ≤10ppm BHT as inhibitor
Supelco
二乙醚, analytical standard
Sigma-Aldrich
棕榈酸棕榈酯, ≥99%
Supelco
棕榈酸棕榈酯, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
二乙醚, reagent grade, ≥98%, contains ≤2% ethanol and ≤10ppm BHT as inhibitor
Sigma-Aldrich
二乙醚, puriss., contains ~5 mg/L 2,6-di-tert.-butyl-4-methylphenol as stabilizer, meets analytical specification of Ph. Eur., BP, ≥99.5% (GC)
棕榈酸棕榈酯, European Pharmacopoeia (EP) Reference Standard
棕榈酸棕榈酯, European Pharmacopoeia (EP) Reference Standard