• 主页
  • 查找结果
  • Mesenchymal Stem Cells Aggregate and Deliver Gold Nanoparticles to Tumors for Photothermal Therapy.

Mesenchymal Stem Cells Aggregate and Deliver Gold Nanoparticles to Tumors for Photothermal Therapy.

ACS nano (2015-09-09)
Seokyung Kang, Suk Ho Bhang, Sekyu Hwang, Jeong-Kee Yoon, Jaejung Song, Hyeon-Ki Jang, Sungjee Kim, Byung-Soo Kim
摘要

Gold nanoparticles (AuNPs) have been extensively studied for photothermal cancer therapy because AuNPs can generate heat upon near-infrared irradiation. However, improving their tumor-targeting efficiency and optimizing the nanoparticle size for maximizing the photothermal effect remain challenging. We demonstrate that mesenchymal stem cells (MSCs) can aggregate pH-sensitive gold nanoparticles (PSAuNPs) in mildly acidic endosomes, target tumors, and be used for photothermal therapy. These aggregated structures had a higher cellular retention in comparison to pH-insensitive, control AuNPs (cAuNPs), which is important for the cell-based delivery process. PSAuNP-laden MSCs (MSC-PSAuNPs) injected intravenously to tumor-bearing mice show a 37-fold higher tumor-targeting efficiency (5.6% of the injected dose) and 8.3 °C higher heat generation compared to injections of cAuNPs after irradiation, which results in a significantly enhanced anticancer effect.

材料
货号
品牌
产品描述

Sigma-Aldrich
纯乙醇, 200 proof, anhydrous, ≥99.5%
Sigma-Aldrich
纯乙醇, 200 proof, for molecular biology
Sigma-Aldrich
纯乙醇, 190 proof, meets USP testing specifications
Sigma-Aldrich
纯乙醇, 190 proof, ACS spectrophotometric grade, 95.0%
Sigma-Aldrich
乙醇, anhydrous, denatured
Sigma-Aldrich
纯乙醇, 200 proof, ACS reagent, ≥99.5%
Sigma-Aldrich
氢氧化钠, reagent grade, ≥98%, pellets (anhydrous)
Sigma-Aldrich
氢氧化钠, ACS reagent, ≥97.0%, pellets
Sigma-Aldrich
氢氧化钠 溶液, 50% in H2O
Sigma-Aldrich
氢氧化钠, BioXtra, ≥98% (acidimetric), pellets (anhydrous)
Sigma-Aldrich
氢氧化钠 溶液, BioUltra, for molecular biology, 10 M in H2O
Sigma-Aldrich
氢氧化钠 溶液, 1.0 N, BioReagent, suitable for cell culture
Sigma-Aldrich
纯乙醇, 200 proof, HPLC/spectrophotometric grade
Sigma-Aldrich
氢氧化钠, puriss., meets analytical specification of Ph. Eur., BP, NF, E524, 98-100.5%, pellets
Sigma-Aldrich
纯乙醇, 200 proof, meets USP testing specifications
Sigma-Aldrich
11-巯基十一烷酸, 95%
Sigma-Aldrich
(±)-环氧丙烷, ReagentPlus®, ≥99%
Sigma-Aldrich
纯乙醇, 190 proof, for molecular biology
Sigma-Aldrich
(±)-α-硫辛酸, suitable for cell culture, BioReagent, ≥99%
Sigma-Aldrich
氢氧化钠, reagent grade, 97%, powder
Sigma-Aldrich
氢氧化钠 溶液, 5.0 M
Sigma-Aldrich
(±)-α-硫辛酸, ≥98.0%
Sigma-Aldrich
乙醇, puriss. p.a., ACS reagent, prima fine spirit, without additive, F15 o1, ~96%
Sigma-Aldrich
柠檬酸 三钠盐, anhydrous, ≥98% (GC)
Sigma-Aldrich
氢氧化钠, puriss. p.a., ACS reagent, reag. Ph. Eur., K ≤0.02%, ≥98%, pellets
Sigma-Aldrich
氢氧化钠, pellets, semiconductor grade, 99.99% trace metals basis
Sigma-Aldrich
(±)-环氧丙烷, puriss. p.a., ≥99.5% (GC)
Sigma-Aldrich
80% v/v 乙醇固定液, suitable for fixing solution (blood films)
Sigma-Aldrich
(±)-α-硫辛酸, synthetic, ≥99% (titration), powder
Sigma-Aldrich
氢氧化钠, puriss. p.a., ACS reagent, K ≤0.02%, ≥98.0% (T), pellets