• 主页
  • 查找结果
  • Functional variations in MBL2 gene are associated with cutaneous leishmaniasis in the Amazonas state of Brazil.

Functional variations in MBL2 gene are associated with cutaneous leishmaniasis in the Amazonas state of Brazil.

Genes and immunity (2015-03-13)
F J de Araujo, T G Mesquita, L D O da Silva, S A de Almeida, W de S Vital, A Chrusciak-Talhari, J A de O Guerra, S Talhari, R Ramasawmy
摘要

Functional variations in the mannose-binding lectin (MBL2) gene causing low levels of serum MBL are associated with susceptibility to numerous infectious diseases. We investigated whether there is genetic association of MBL2 variant alleles with cutaneous leishmaniasis (CL) caused by Leishmania guyanensis. We used PCR-restriction fragment length polymorphism to genotype six MBL2 variants, three in the promoter region and three in the exon 1. An association was noted between the single nucleotide polymorphism -221X/Y of the MBL2 gene and CL (P=2.9 × 10(-6); odds ratio (OR)=1.9 (1.4-2.5) consistent with the hypothesis that the -221X allele confers high risk to development of CL among L. guyanensis-infected individuals. Furthermore, L. guyanensis-infected individuals bearing the codon 57 allele C had a higher risk of developing CL (P=5 × 10(-5); OR=1.9 (1.4-2.6)). The low MBL expressor haplotype LXPB was also associated to CL (P=6 × 10(-4)). This study raises the possibility that functional polymorphisms in MBL2 gene play a role in clinical outcome of Leishmania infection.

材料
货号
品牌
产品描述

Sigma-Aldrich
氯化镁, anhydrous, ≥98%
Sigma-Aldrich
氯化镁 溶液, for molecular biology, 1.00 M±0.01 M
Sigma-Aldrich
氯化镁 溶液, BioUltra, for molecular biology, ~1 M in H2O
Sigma-Aldrich
D-(+)-甘露糖, powder, BioReagent, suitable for cell culture
Sigma-Aldrich
氯化镁, powder, <200 μm
Sigma-Aldrich
氯化镁 溶液, BioUltra, for molecular biology, 2 M in H2O
Sigma-Aldrich
锡, ≥99%, powder
Sigma-Aldrich
D-(+)-甘露糖, synthetic, ≥99%
Sigma-Aldrich
氯化镁, BioReagent, suitable for insect cell culture, ≥97.0%
Sigma-Aldrich
D-(+)-甘露糖, wood, ≥99%
Sigma-Aldrich
氯化镁 溶液, PCR Reagent, 25 mM MgCI2 solution for PCR
Sigma-Aldrich
锡, powder, <150 μm, 99.5% trace metals basis
Sigma-Aldrich
锡, nanopowder, <150 nm particle size (SEM), ≥99% trace metals basis
Sigma-Aldrich
锡, granular, 0.425-2.0 mm particle size, ≥99.5%, ACS reagent
Sigma-Aldrich
氯化镁, AnhydroBeads, −10 mesh, 99.99% trace metals basis
Sigma-Aldrich
D-(+)-甘露糖, BioUltra, ≥99.5% (sum of enantiomers, HPLC)
Sigma-Aldrich
锡, foil, thickness 0.5 mm, 99.998% trace metals basis
Sigma-Aldrich
锡, powder, -100 mesh, 99.99% trace metals basis
Sigma-Aldrich
锡, powder, <45 μm particle size, 99.8% trace metals basis
Sigma-Aldrich
锡, shot, 99.999% trace metals basis
Sigma-Aldrich
锡, powder, 10 μm, 99% trace metals basis
Sigma-Aldrich
氯化镁 溶液, 0.1 M
Sigma-Aldrich
氯化镁, AnhydroBeads, −10 mesh, 99.9% trace metals basis
Sigma-Aldrich
锡, 99.8%, shot, 3 mm
Sigma-Aldrich
锡, wire, diam. 0.5 mm, 99.999% trace metals basis
Sigma-Aldrich
锡, foil, thickness 0.127 mm, 99.9%
Sigma-Aldrich
氯化镁 溶液, BioUltra, for molecular biology, ~0.025 M in H2O
锡, rod, 100mm, diameter 2.0mm, 99.999+%
锡, foil, 150x150mm, thickness 0.20mm, as rolled, 98.8%
锡, foil, 0.5m coil, thickness 0.009mm, 97.4%

社交媒体

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

Merck

科研、开发、生产。

作为生命科学行业的全球领先供应商,我们致力于为科研、生物技术开发和生产,以及制药药物疗法开发和生产提供各类解决方案和服务。

© 2021年版权归德国达姆施塔特默克集团(Merck KGaA)及/或其附属公司所有。版权所有。

未经许可,严禁复制本网站上的任何资料。