• 主页
  • 查找结果
  • Solanum tuberosum L. cv Jayoung Epidermis Extract Inhibits Mite Antigen-Induced Atopic Dermatitis in NC/Nga Mice by Regulating the Th1/Th2 Balance and Expression of Filaggrin.

Solanum tuberosum L. cv Jayoung Epidermis Extract Inhibits Mite Antigen-Induced Atopic Dermatitis in NC/Nga Mice by Regulating the Th1/Th2 Balance and Expression of Filaggrin.

Journal of medicinal food (2015-06-24)
Gabsik Yang, Se-Yun Cheon, Kyung-Sook Chung, Sung-Jin Lee, Chul-Hee Hong, Kyung-Tae Lee, Dae-Sik Jang, Jin-Cheol Jeong, Oh-Keun Kwon, Jung-Hwan Nam, Hyo-Jin An
摘要

Solanum tuberosum L. cv Jayoung (JY) is a potato with dark purple flesh and contains substantial amounts of polyphenols. In this study, we evaluated the therapeutic effects of S. tuberosum L. cv JY in a mouse model of Dermatophagoides farinae body (Dfb)-induced atopic dermatitis (AD). The ethanol extract of the peel of JY (EPJ) ameliorated Dfb-induced dermatitis severity, serum levels of immunoglobulin E (IgE) and thymus and activation-regulated chemokine. Histological analysis of the skin also revealed that EPJ treatment significantly decreased mast cell infiltration. The suppression of dermatitis by EPJ treatment was accompanied by a decrease in the skin levels of type 2 helper T-cell cytokines such as interleukin (IL)-4, IL-5, and IL-13. The induction of thymic stromal lymphopoietin, which leads to a systemic Th2 response, was also decreased in the skin by EPJ. Nuclear translocation of nuclear factor-κB p65 was decreased by EPJ in Dfb-induced NC/Nga mice. The protein expression of filaggrin in the AD-like skin lesions was restored by EPJ treatment. These results suggested that EPJ may be a potential therapeutic tool for the treatment of AD.

材料
货号
品牌
产品描述

Sigma-Aldrich
羟乙基哌嗪乙硫磺酸, ≥99.5% (titration)
Sigma-Aldrich
甲醛 溶液, ACS reagent, 37 wt. % in H2O, contains 10-15% Methanol as stabilizer (to prevent polymerization)
Sigma-Aldrich
羟乙基哌嗪乙硫磺酸, BioPerformance Certified, ≥99.5% (titration), suitable for cell culture
Sigma-Aldrich
甲醛 溶液, for molecular biology, 36.5-38% in H2O
Sigma-Aldrich
氯化镁, anhydrous, ≥98%
Sigma-Aldrich
氯化镁 溶液, for molecular biology, 1.00 M±0.01 M
Sigma-Aldrich
HEPES缓冲溶液, 1 M in H2O
Sigma-Aldrich
甲醛 溶液, for molecular biology, BioReagent, ≥36.0% in H2O (T)
SAFC
羟乙基哌嗪乙硫磺酸
Sigma-Aldrich
氯化镁, powder, <200 μm
Sigma-Aldrich
氯化镁 溶液, BioUltra, for molecular biology, ~1 M in H2O
Sigma-Aldrich
羟乙基哌嗪乙硫磺酸, BioUltra, for molecular biology, ≥99.5% (T)
Sigma-Aldrich
甲醛 溶液, meets analytical specification of USP, ≥34.5 wt. %
Sigma-Aldrich
氯化镁 溶液, BioUltra, for molecular biology, 2 M in H2O
Sigma-Aldrich
氯化镁, BioReagent, suitable for insect cell culture, ≥97.0%
Sigma-Aldrich
氯化镁 溶液, PCR Reagent, 25 mM MgCI2 solution for PCR
SAFC
羟乙基哌嗪乙硫磺酸
Sigma-Aldrich
羟乙基哌嗪乙硫磺酸, BioXtra, pH 5.0-6.5 (1 M in H2O), ≥99.5% (titration)
Sigma-Aldrich
羟乙基哌嗪乙硫磺酸, BioXtra, suitable for mouse embryo cell culture, ≥99.5% (titration)
Sigma-Aldrich
氯化镁, AnhydroBeads, −10 mesh, 99.99% trace metals basis
Sigma-Aldrich
氯化镁, AnhydroBeads, −10 mesh, 99.9% trace metals basis
Sigma-Aldrich
羟乙基哌嗪乙硫磺酸, anhydrous, free-flowing, Redi-Dri, ≥99.5%
Sigma-Aldrich
氯化镁 溶液, BioUltra, for molecular biology, ~0.025 M in H2O
Sigma-Aldrich
氯化镁 溶液, 0.1 M
Sigma-Aldrich
甲醛-12C 溶液, 20% in H2O, 99.9 atom % 12C