Merck
  • Home
  • Search Results
  • The Role of Charge Density and Hydrophobicity on the Biocidal Properties of Self-Protonable Polymeric Materials.

The Role of Charge Density and Hydrophobicity on the Biocidal Properties of Self-Protonable Polymeric Materials.

Macromolecular bioscience (2015-03-18)
Simona Matrella, Carmela Vitiello, Massimo Mella, Giovanni Vigliotta, Lorella Izzo
ABSTRACT

Intrinsic antimicrobial thermoplastic A(BC)n copolymers (n = 1, 2, 4), where A was poly(ethylene glycol) (PEG), BC was a random chain of methylmethacrylate (MMA), and alkyl-aminoethyl methacrylate (AAEMA), were synthesized and the antimicrobial activity and hemolyticity were evaluated on plaques obtained by casting as a function of the architecture, the N-substituent groups of the AAEMAs (methyl, ethyl, isopropyl, and tert-butyl groups) and the hydrophobic/charge density balance. Antimicrobial effectiveness and efficiency is controlled by the surface charge density and by the influence of N-alkyl groups on the surface morphology. Also interestingly, it is the absence of hemolitytic activity in all copolymers. In presence of Escherichia coli, the A(BC)2 copolymer with 40% of N-methyl groups is the most efficient, killing 91% of the bacteria already after 1.5 h.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
二氯甲烷, anhydrous, ≥99.8%, contains 40-150 ppm amylene as stabilizer
Sigma-Aldrich
甲苯, anhydrous, 99.8%
Sigma-Aldrich
纯乙醇, 200 proof, anhydrous, ≥99.5%
Sigma-Aldrich
甲醇, anhydrous, 99.8%
Sigma-Aldrich
吡啶, anhydrous, 99.8%
Sigma-Aldrich
三乙基胺, ≥99.5%
Sigma-Aldrich
二乙醚, contains 1 ppm BHT as inhibitor, anhydrous, ≥99.7%
Sigma-Aldrich
三乙基胺, ≥99%
Sigma-Aldrich
氯仿, anhydrous, ≥99%, contains 0.5-1.0% ethanol as stabilizer
Sigma-Aldrich
三乙基胺, puriss. p.a., ≥99.5% (GC)
Sigma-Aldrich
p-甲苯磺酸 一水合物, ACS reagent, ≥98.5%
Sigma-Aldrich
氯仿, anhydrous, contains amylenes as stabilizer, ≥99%
Sigma-Aldrich
4-(二甲氨基)吡啶, ReagentPlus®, ≥99%
Sigma-Aldrich
丙酸, ACS reagent, ≥99.5%
Sigma-Aldrich
N,N′-二环己基碳二亚胺, 99%
Sigma-Aldrich
纯乙醇, 190 proof, ACS spectrophotometric grade, 95.0%
Sigma-Aldrich
纯乙醇, 190 proof, meets USP testing specifications
Sigma-Aldrich
三乙基胺, BioUltra, ≥99.5% (GC)
Sigma-Aldrich
p-甲苯磺酸 一水合物, ReagentPlus®, ≥98%
Sigma-Aldrich
乙醇, anhydrous, denatured
Sigma-Aldrich
西曲氯铵 溶液, 25 wt. % in H2O
Sigma-Aldrich
α-溴异丁酰溴, 98%
Sigma-Aldrich
二氯甲烷, suitable for HPLC, ≥99.9%, contains 40-150 ppm amylene as stabilizer
Sigma-Aldrich
十六烷基三甲基氯化铵, ≥98.0% (NT)
Sigma-Aldrich
苯甲醛二甲缩醛, 99%
Sigma-Aldrich
p-甲苯磺酸 一水合物, ≥99% (calc. to H2O free subst.)
Sigma-Aldrich
二甲醚, ≥99%
Sigma-Aldrich
丙酸, ≥99.5%, FCC, FG
Sigma-Aldrich
丙酮, suitable for HPLC, ≥99.9%
Sigma-Aldrich
三乙基胺, for amino acid analysis, ≥99.5% (GC)