• 主页
  • 查找结果
  • Analysis of Five Gene Sets in Chimpanzees Suggests Decoupling between the Action of Selection on Protein-Coding and on Noncoding Elements.

Analysis of Five Gene Sets in Chimpanzees Suggests Decoupling between the Action of Selection on Protein-Coding and on Noncoding Elements.

Genome biology and evolution (2015-05-16)
Gabriel Santpere, Elena Carnero-Montoro, Natalia Petit, François Serra, Christina Hvilsom, Jordi Rambla, Jose Maria Heredia-Genestar, Daniel L Halligan, Hernan Dopazo, Arcadi Navarro, Elena Bosch
摘要

We set out to investigate potential differences and similarities between the selective forces acting upon the coding and noncoding regions of five different sets of genes defined according to functional and evolutionary criteria: 1) two reference gene sets presenting accelerated and slow rates of protein evolution (the Complement and Actin pathways); 2) a set of genes with evidence of accelerated evolution in at least one of their introns; and 3) two gene sets related to neurological function (Parkinson's and Alzheimer's diseases). To that effect, we combine human-chimpanzee divergence patterns with polymorphism data obtained from target resequencing 20 central chimpanzees, our closest relatives with largest long-term effective population size. By using the distribution of fitness effect-alpha extension of the McDonald-Kreitman test, we reproduce inferences of rates of evolution previously based only on divergence data on both coding and intronic sequences and also obtain inferences for other classes of genomic elements (untranslated regions, promoters, and conserved noncoding sequences). Our results suggest that 1) the distribution of fitness effect-alpha method successfully helps distinguishing different scenarios of accelerated divergence (adaptation or relaxed selective constraints) and 2) the adaptive history of coding and noncoding sequences within the gene sets analyzed is decoupled.

材料
货号
品牌
产品描述

Sigma-Aldrich
锡, ≥99%, powder
Sigma-Aldrich
锡, powder, <150 μm, 99.5% trace metals basis
Sigma-Aldrich
锡, nanopowder, <150 nm particle size (SEM), ≥99% trace metals basis
Sigma-Aldrich
锡, granular, 0.425-2.0 mm particle size, ≥99.5%, ACS reagent
Sigma-Aldrich
锡, foil, thickness 0.5 mm, 99.998% trace metals basis
Sigma-Aldrich
锡, powder, -100 mesh, 99.99% trace metals basis
Sigma-Aldrich
锡, powder, <45 μm particle size, 99.8% trace metals basis
Sigma-Aldrich
锡, shot, 99.999% trace metals basis
Sigma-Aldrich
锡, powder, 10 μm, 99% trace metals basis
Sigma-Aldrich
锡, 99.8%, shot, 3 mm
Sigma-Aldrich
锡, wire, diam. 0.5 mm, 99.999% trace metals basis
Sigma-Aldrich
锡, foil, thickness 0.127 mm, 99.9%
锡, rod, 100mm, diameter 2.0mm, 99.999+%
锡, foil, 150x150mm, thickness 0.20mm, as rolled, 98.8%
锡, foil, 0.5m coil, thickness 0.009mm, 97.4%
锡, foil, 100x100mm, thickness 0.125mm, as rolled, 98.8%
锡, foil, 100x100mm, thickness 0.125mm, as rolled, 99.99+%
锡, foil, 100x100mm, thickness 0.15mm, as rolled, 98.8%
锡, foil, 100x100mm, thickness 0.15mm, as rolled, 99.99+%
锡, foil, 100x100mm, thickness 0.1mm, as rolled, 98.8%
锡, foil, 100x100mm, thickness 0.1mm, as rolled, 99.95%
锡, foil, 100x100mm, thickness 0.20mm, as rolled, 98.8%
锡, foil, 100x100mm, thickness 0.25mm, as rolled, 98.8%
锡, foil, 100x100mm, thickness 0.25mm, as rolled, 99.99+%
锡, foil, 100x100mm, thickness 0.5mm, as rolled, 98.8%
锡, foil, 100x100mm, thickness 0.5mm, as rolled, 99.99+%
锡, foil, 100x100mm, thickness 0.65mm, as rolled, 99.99+%
锡, foil, 100x100mm, thickness 0.75mm, as rolled, 99.99+%
锡, foil, 100x100mm, thickness 1.0mm, as rolled, 98.8%
锡, foil, 100x100mm, thickness 1.0mm, as rolled, 99.99+%

社交媒体

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

Merck

科研、开发、生产。

作为生命科学行业的全球领先供应商,我们致力于为科研、生物技术开发和生产,以及制药药物疗法开发和生产提供各类解决方案和服务。

© 2021年版权归德国达姆施塔特默克集团(Merck KGaA)及/或其附属公司所有。版权所有。

未经许可,严禁复制本网站上的任何资料。