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  • Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release.

Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release.

Proceedings of the National Academy of Sciences of the United States of America (2017-03-08)
Chuchu Zhang, Katalin F Medzihradszky, Elda E Sánchez, Allan I Basbaum, David Julius
摘要

Pain-producing animal venoms contain evolutionarily honed toxins that can be exploited to study and manipulate somatosensory and nociceptive signaling pathways. From a functional screen, we have identified a secreted phospholipase A2 (sPLA2)-like protein, BomoTx, from the Brazilian lancehead pit viper (

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