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N6803

Sigma-Aldrich

Nystatin water soluble

suitable for cell culture

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biological source

synthetic

form

powder

mol wt

1029.23 g/mol

technique(s)

cell culture | mammalian: suitable

solubility

100 mg/mL

shipped in

dry ice

storage temp.

−20°C

Related Categories

General description

Nystatin is a polyene, broad-spectrum antibiotic. It can modify the microstructure of lipid rafts and sequestrate cholesterol present on the cell membrane of eukaryotes. Thus, nystatin can modulate immune responses. This is carried out through cytokine signaling, activation of lymphocytes and pathogen recognition.
Molecular Formula: C51H84N2O19
Molecular Weight: 1029.23
Nystatin water soluble is a Nystatin derivate with fungistatic and fungicidal activity in resemblance to Nystatin. However, as opposed to the poor solubility of Nystatin the water soluble derivate can be dissolved in concentration of up to 100mg/ml. Nystatin binds to ergosterol which increases cell membrane permeability in sensitive fungi. Nystatin is mainly clinically active against Candida species. However, it is also reported to be effective against Aspergillus, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatidis, and other yeasts and fungi. Nystatin has also been used to enrich mutants by negative selection in yeasts. The minimum inhibitory concentration (MIC) of Nystatin to Saccharomyces cerevisiae was reported to be 3μg/ml while for clinical isolates of Candida albicans the MIC was reported to be 4-16μg/ml.

Other Notes

Technical data

  • Nystatin water soluble is a fully solubilized powder of Nystatin with potency of ≥2000 units/mg according to USP standard.
  • Nystatin water soluble is 0.2μm filtered and endotoxin free.
  • The suggest working concentration of Nystatin water soluble is 100 units/ml.
  • It is recommended to store solutions of Nystatin water soluble in the dark.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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