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C–C Bond Forming Reagents

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Carbon-carbon (C–C) bond formation is a fundamental transformation of synthetic organic chemistry. The ability to elaborate and extend a carbon framework via a series of C–C bond-forming reactions is paramount to medicinal chemistry, agrochemical synthesis, and natural product synthesis. 

Tremendous advances have been made in the synthetic methods available for C–C bond formation due to the development of robust and reliable protocols for cross-coupling, increased accessibility to various organometallic reagents, and the creation and improvement of stoichiometric reagents which serve to place a specific carbon-containing moiety. 

We have a wide breadth of powerful C–C bond-forming reagents. Our phosphonium salts are used in Wittig reactions, and phosphonates are employed in Horner-Wadsworth-Emmons (HWE) reactions to create various alkene-containing products. We have a diverse selection of reagents for trifluoromethylation and difluoromethylation, many of which can be employed under mild conditions and have broad substrate scopes. Our extensive array of palladium, ruthenium, and other metal precatalysts and catalysts are optimal for various cross-coupling reactions. Additional carbon-carbon bond-forming reagents include boronic acids and derivatives, alkynes, triflates, and halogenated substrates. In addition, we have various catalysts for olefin and alkyne metathesis available for your research.

Trigger your organic reactions with our carbon-carbon bond-forming reagents to reach your new frontiers. 

Products

C-C Bond Formation (178)

C-H Activation (26)

Olefinations (3)

Whiting Reaction (3)

Fluorinations (2)

Allylation (1)

catalyst (27)

diversification reagent (4)

ligand (3)

linker (2)

cross-linking reagent (1)

powder (49)

solid (49)

liquid (37)

powder or crystals (7)

crystals (3)

crystalline (1)
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Ethylene oxide solution
779202

Ethylene oxide solution

2.5-3.3 M in THF

Methyltriphenylphosphonium bromide
130079

Methyltriphenylphosphonium bromide

98%

Dimethyl methylphosphonate
D169102

Dimethyl methylphosphonate

≥98%

<I>N</I>,<I>N</I>-Dimethylformamide dimethyl acetal
140732

N,N-Dimethylformamide dimethyl acetal

technical grade, 94%

Trimethyl(trifluoromethyl)silane
488712

Trimethyl(trifluoromethyl)silane

99%

Benzyltriphenylphosphonium chloride
B32807

Benzyltriphenylphosphonium chloride

99%

(Carbethoxymethylene)triphenylphosphorane
C5106

(Carbethoxymethylene)triphenylphosphorane

95%

Tetrakis(dimethylamino)ethylene
674613

Tetrakis(dimethylamino)ethylene

Triethyl phosphonoacetate
T61301

Triethyl phosphonoacetate

98%

Dimethyl methylphosphonate
64258

Dimethyl methylphosphonate

purum, ≥97.0% (GC)

Trimethyl phosphonoacetate
T79758

Trimethyl phosphonoacetate

98%

(Methoxymethyl)triphenylphosphonium chloride
309567

(Methoxymethyl)triphenylphosphonium chloride

97%

Sodium triflinate
743232

Sodium triflinate

≥95.0% (T)

Methyl (triphenylphosphoranylidene)acetate
157929

Methyl (triphenylphosphoranylidene)acetate

98%

Trimethylsulfonium iodide
T80489

Trimethylsulfonium iodide

98%

Dimethyl (1-diazo-2-oxopropyl)phosphonate solution
742724

Dimethyl (1-diazo-2-oxopropyl)phosphonate solution

~10% in acetonitrile (H-NMR), ≥96% (HPLC)

2-(2-Hydroxy-5-methylphenyl)benzotriazole
533203

2-(2-Hydroxy-5-methylphenyl)benzotriazole

97%

(4-Carboxybutyl)triphenylphosphonium bromide
157945

(4-Carboxybutyl)triphenylphosphonium bromide

98%

(Chloromethylene)dimethyliminium chloride
280909

(Chloromethylene)dimethyliminium chloride

95%

Copper(I) thiophene-2-carboxylate
682500

Copper(I) thiophene-2-carboxylate

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