100105

A23187 free acid

from Streptomyces chartreusensis, ≥98% (TLC), solid, mitochondrial ATPase inhibitor, Calbiochem^®

• Szinonimák: A23187, Free Acid, Streptomyces chartreusensis, Calcimycin
• Tapasztalati képlet (Hill-képlet): C₂₉H₃₇N₃O₆
• CAS-szám: 52665-69-7
• Molekulatömeg: 523.62
• MDL-szám: MFCD00151202
• UNSPSC kód: 12352106
• NACRES: NA.77

Tulajdonságok

• Termék neve: A23187, Free Acid, Streptomyces chartreusensis, A mobile ion-carrier that forms stable complexes with divalent cations.
• Minőségi szint: 100
• leírás: Merck USA index - 14, 1639
• Teszt: ≥98% (TLC)
• Forma: solid
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze; protect from light
• szín: white
• oldhatóság: DMSO: soluble; methanol: soluble
• kiszállítva: ambient
• tárolási hőmérséklet: 2-8°C
• SMILES string: [nH]1c(ccc1)C(=O)C([C@H]2OC3(O[C@H]([C@H](CC3)C)Cc4nc5c([o]4)ccc(c5C(=O)O)NC)[C@@H](C[C@H]2C)C)C
• InChI: 1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16+,17+,18?,22-,27-,29?/m0/s1
• Nemzetközi kémiai azonosító kulcs: HIYAVKIYRIFSCZ-CVXKHCKVSA-N

Leírás

Általános leírás

A mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca²⁺ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.

Biokémiai/fiziológiai hatások

Cell permeable: no

Primary Target
Mitochondrial ATPase

Product does not compete with ATP.

Reversible: no

Elkészítési megjegyzés

For use in aqueous systems, preparation of a 100 mM stock in DMSO is recommended. Microliter amounts of this solution can then be added to H₂O with rapid mixing (e.g. 10 µl into 5 ml of H₂O). In aqueous systems, the ionophore aggregates over time.

Egyéb megjegyzések

Caron-Leslie, L.A., et al. 1994. FASEB J.8, 639.
Saunders, M.J., and Hepler, P.K. 1982. Science217, 943.
Pressman, B.C. 1976. Annu. Rev. Biochem. 45,501.
Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Jogi nyilatkozat

Toxicity: Standard Handling (A)

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable