124034

Akt Inhibitor XV, Isozyme-Selective

The Akt Inhibitor XV, Isozyme-Selective controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Szinonimák: Akt Inhibitor XV, Isozyme-Selective, 5-Hydroxy-3-phenyl-2-(4-((4-(5-pyridin-2-yl-1H-1,2,4-triazol-3-yl)piperdin-1-yl)methyl)phenyl)-1,6-naphthyridine
• Tapasztalati képlet (Hill-képlet): C₃₃H₂₉N₇O
• Molekulatömeg: 539.63
• UNSPSC Code: 12352200

Tulajdonságok

• Termék neve: Akt Inhibitor XV, Isozyme-Selective, The Akt Inhibitor XV, Isozyme-Selective controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
• assay: ≥97% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: DMSO: 25 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• Quality Level: 100

Leírás

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable naphthyridinone compound that acts as an allosteric Akt1/2-selective inhibitor (IC₅₀ = 3.5, 42, and 1900 nM against Akt1, Akt2, and Akt3, respectively) in a PH domain-dependent, but not ATP-competitive, manner, with little activity against a panel of more than 160 other kinases, including the related AGC family kinases (inactive at 10 µM against GSK, PDK1, PKA, PKC, and SGK). Effectively inhibits the basal Akt phosphorylation in cancer cells with deregulated Akt pathway activation, including the HCT116 colorectal carcinoma and a panel of breast cancer cell lines (IC₅₀<500 nM), and suppresses Akt-dependent cell growth both in cultures in vitro (IC₅₀ ≤1 µM) and in mice in vivo (50 to 100 mg/kg, SC). Although also referred to as AKTi-1/2, this is not the same compound as Akt Inhibitor XV (Cat. Nos. 124017 & 124018).

Other Notes

She, Q.B., et al. 2010. Cancer Cell18, 39.
Bilodeau, M.T., et al. 2008. Bioorg. Med. Chem. Lett.18, 3178.
She, Q.B, et al. 2008. PLoS One3, e3065.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable