234115

Colchicine

From Colchicum autumnale, is an inhibitor of mitosis that disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in PC12 and cerebellar granule cells

• Szinonimák: Colchicine, Colchicum autumnale
• Tapasztalati képlet (Hill-képlet): C₂₂H₂₅NO₆
• CAS-szám: 64-86-8
• Molekulatömeg: 399.44
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00078484
• Assay: ≥94% (HPLC)
• Form: powder
• Storage condition: OK to freeze, protect from light

Tulajdonságok

• Termék neve: Colchicine, Colchicum autumnale, Colchicine, Colchicum autumnale, CAS 64-86-8, is an inhibitor of mitosis that disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in PC12 and cerebellar granule cells.
• Quality Segment: 100
• description: Merck USA index - 14, 2471
• assay: ≥94% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: yellow to off-white
• solubility: ethanol: 10 mg/mL, water: soluble
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: N([C@H]1CCc2c(c(c(c(c2)OC)OC)OC)c3c1c[c](c(cc3)OC)=O)C(=O)C
• InChI: 1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
• InChI key: IAKHMKGGTNLKSZ-INIZCTEOSA-N

Leírás

General description

Inhibitor of mitosis that is useful in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in PC12 cells and in cerebellar granule cells.

Major alkaloid of Colchicum autumnale. Inhibitor of mitosis used in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in pheochromocytoma (PC12) cells and in cerebellar granule cells.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Inhibitor of mitosis

Product does not compete with ATP.

Reversible: no

Other Notes

Bonfoco, E., et al. 1995. Exp. Cell Res.218, 189.
Lindenboim, L., et al. 1995. J. Neurochem.64, 1054.
Leung, M.F., and Sartorelli, A.C. 1992. Leuk. Res.16, 929.
Santell, L. 1992. Exp. Cell Res. 201, 358.
Salmon, E.D., et al. 1984. J. Cell Biol.99, 1066.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

Biztonsági adatok

• Piktogramok: GHS06,GHS08
• Figyelmeztető szó: Danger
• Veszélykódok: H300,H340
• Biztonsági figyelmeztetések: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral - Muta. 1B
• Tárolási osztály: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Mi folyik itt?: WGK 3
• Lobbanáspont (°F): Not applicable
• Lángpont (°C): Not applicable