The intended storage temperature for this product is room temperature. A desiccator is not required for storage.
M3262
N-Methyl-D-aspartic acid
≥98% (TLC), suitable for cell culture
Szinonimák:
(R)-2-(Methylamino)succinic acid, NMDA
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Méret kiválasztása
25 MG
27 000,00 Ft
100 MG
59 300,00 Ft
250 MG
141 000,00 Ft
1 G
424 000,00 Ft
27 000,00 Ft
Az elérhetőséggel kapcsolatos kérdésekkel kérjük, forduljon Vevőszolgálatunkhoz.
Erről a tételről
Tapasztalati képlet (Hill-képlet):
C5H9NO4
CAS-szám:
Molekulatömeg:
147.13
Beilstein:
1724431
MDL-szám:
UNSPSC kód:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.32
Ugrás ide:
Műszaki ügyfélszolgálat
Segítségre van szüksége? Szakértő tudósaink csapata készséggel áll az Ön rendelkezésére.
Segíthetünk?Termék neve
N-Methyl-D-aspartic acid, ≥98% (TLC), solid
Minőségi szint
Teszt
≥98% (TLC)
Forma
solid
technika/technikák
cell culture | mammalian: suitable
szín
white
mp
189-190 °C
alkalmazás(ok)
cell analysis
SMILES string
CN[C@H](CC(O)=O)C(O)=O
InChI
1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1
Nemzetközi kémiai azonosító kulcs
HOKKHZGPKSLGJE-GSVOUGTGSA-N
Géninformáció
human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)
rat ... Gria1(50592), Grik1(29559), Grin2a(24409)
Hasonló termékeket keres? Látogasson el ide Útmutató a termékösszehasonlításhoz
Kapcsolódó kategóriák
1 of 4
Ez a tétel | A7219 | 454575 | G1001 |
|---|---|---|---|
| form solid | form powder | form solid | form powder |
| assay ≥98% (TLC) | assay 98.5-101.0% | assay >95% (TLC) | assay ≥99% (TLC) |
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) ligand binding assay: suitable |
| Quality Level 200 | Quality Level 300 | Quality Level 100 | Quality Level 200 |
| color white | color white to off-white | color white | color white to off-white |
| mp 189-190 °C | mp >300 °C (dec.) (lit.) | mp - | mp 200-202 °C (subl.) (lit.) |
Általános leírás
N-Methyl-D-aspartic acid (NMDA) is an endogenously generated molecule in rat nervous system and endocrine glands. NMDA is present at low level (nmol/g) in the adenohypophysis, hypothalamus, brain, and testis. NMDA is derived from D-Asp by an S-adenosylmethionine-dependent enzyme also referred to as NMDA synthase.[1]
Alkalmazás
Biokémiai/fiziológiai hatások
Excitotoxic amino acid. Prototypic agonist at the NMDA-type glutamate receptor that regulates ion channels; important in long-term potentiation, ischemia, and epilepsy.
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Egyéni védőeszköz
Eyeshields, Gloves, type N95 (US)
Válasszon a legfrissebb verziók közül:
Már rendelkezik ezzel a termékkel?
Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.
Juan Ding et al.
Neural regeneration research, 14(12), 2112-2117 (2019-08-10)
N-methyl-D-aspartate receptor hypofunction is the basis of pathophysiology in schizophrenia. Blocking the N-methyl-D-aspartate receptor impairs learning and memory abilities and induces pathological changes in the brain. Previous studies have paid little attention to the role of the N-methyl-D-aspartate receptor subunit
Guendalina Olivero et al.
Molecular neurobiology, 56(9), 6142-6155 (2019-02-09)
Mouse hippocampal glutamatergic nerve endings express presynaptic release-regulating NMDA autoreceptors (NMDARs). The presence of GluN1, GluN2A, GluN2B, and GluN3A subunits in hippocampal vesicular glutamate transporter type 1-positive synaptosomes was confirmed with confocal microscopy. GluN2C, GluN2D, and GluN3B immunopositivity was scarcely
Occurrence of D-aspartic acid and N-methyl-D-aspartic acid in rat neuroendocrine tissues and their role in the modulation of luteinizing hormone and growth hormone release.
D'Aniello A
Faseb Journal, 14(5), 699-714 (2000)
N-methyl-D-aspartic acid (NMDA) in the nervous system of the amphioxus Branchiostoma lanceolatum.
D'Aniello S
BMC Neuroscience, 8:109 (2007)
Calpain- and caspase-mediated aII-spectrin
and tau proteolysis in rat cerebrocortical
neuronal cultures after ecstasy or
methamphetamine exposure.
and tau proteolysis in rat cerebrocortical
neuronal cultures after ecstasy or
methamphetamine exposure.
Warren MW
The International Journal of Neuropsychopharmacology, 9, 1-11 (2006)
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How should the powder be stored? At room temperature or at -20 C? Is a desiccator required if storing at room temp?
1 answer-
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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Which liquid storage form is recommended? And how long do you guarantee a stable dissolved product? How should the dissolved product be stored?
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This product is soluble in water at 50mg/mL. Following reconstitution, store refrigerated at 2 - 8°C for several days at 4°C. For long term storage, stock solutions may be stored in aliquots at -20°C.
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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