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Merck

AR

androgen receptor

Synonyms:
AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM
Species:
Human AR (367), Mouse Ar (11835), Rat Ar (24208), fruit fly ar (44503), Zebrafish ar (100005148), chicken AR (422165), dog AR (403588), domestic cat AR (101081787), domestic cat AR (751827), Horse AR (100033980) ...More
UniProtKB ID:
P10275, A2RUN2, B1AKD7, Q9UD95
Gene ID:
  • Human(367) Summary: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
  • Mouse(11835) androgen receptor
  • Rat(24208) androgen receptor
  • fruit fly(44503) abdomen rotatum
  • Zebrafish(100005148) androgen receptor
  • chicken(422165) androgen receptor
  • dog(403588) androgen receptor
  • domestic cat(101081787) androgen receptor
  • domestic cat(751827) androgen receptor
  • Horse(100033980) androgen receptor
  • cow(280675) androgen receptor
  • sheep(443042) androgen receptor
  • Goat(100860827) androgen receptor
  • Domestic Rabbit(100009193) androgen receptor
  • domestic guinea pig(100726891) androgen receptor

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Small Molecule - Activator

Product Number
Description
Species
E8750
α-Estradiol, powder, ≥98% (TLC),
Species
human, rat
N4128
19-Norethindrone, ≥98%, powder,
Species
human, rat
484431
Propylene glycol monomethyl ether acetate, ReagentPlus®, ≥99.5%,
Species
human
R5010
Resveratrol, ≥99% (HPLC),
Species
human, rat, mouse
D4628
Diethylstilbestrol, ≥99% (HPLC),
Species
human, mouse, rat

Small Molecule - Agonist

Product Number
Description
Species
BP164
Fluoxymesterone, British Pharmacopoeia (BP) Reference Standard,
Species
human
SML0437
Oxandrolone, ≥98% (HPLC),
Species
human
T0250000
Testosterone enantate, European Pharmacopoeia (EP) Reference Standard,
Species
human
M-912
Methandienone solution, 1.0 mg/mL in 1,2-dimethoxyethane, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
1647001
Testosterone cypionate, United States Pharmacopeia (USP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Z0417
β-Zearalanol, ~98% (HPLC),
Species
rat
Z0166
α-Zearalenol, ,
Species
rat
442842
Benzophenone, analytical standard,
Species
rat
C62808
3-Chlorophenol, 98%,
Species
rat
Y0000829
Nilutamide, European Pharmacopoeia (EP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
SAB4501574
Anti-Androgen Receptor, N-Terminal antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence
immunohistochemistry
WH0000367M1
Monoclonal Anti-AR antibody produced in mouse, clone 1G3, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
proximity ligation assay
western blot
04-078
Anti-phospho-Androgen Receptor (Ser81) Antibody, rabbit monoclonal, culture supernatant, Upstate®,
Species Reactivity
human
Application
western blot
SAB5500006
Anti-Androgen Receptor antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP107, affinity isolated antibody,
Species Reactivity
dog, human, mouse, pig, rat
Application
immunohistochemistry
SAB4300098
Anti-phospho-AR (pSer213) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot

Small Molecule - Blocker

Product Number
Description
Species
F9397
Flutamide, ,
Species
mouse, rat, human

Small Molecule - Inhibitor

Product Number
Description
Species
136123
trans-Chalcone, 97%,
Species
rat, human
SML1375
Galeterone, ≥98% (HPLC),
Species
human
158348
4-(Benzyloxy)phenol, 98%,
Species
rat, human
T1875
Testosterone propionate, solid,
Species
human, rat
S3378
Spironolactone, 97.0-103.0%,
Species
rat, human

Small Molecule - Ligand

Product Number
Description
Species
46923
Testosterone, VETRANAL®, analytical standard,
Species
human
86500
Testosterone, purum, ≥99.0% (HPLC),
Species
human
H4637
4-Hydroxyestradiol, ,
Species
rat, human
T5648
Tamoxifen, ≥99%,
Species
human, rat
T1500
Testosterone, ≥98%,
Species
mouse, human, rat

Proteins

Product Number
Description
Species
346101-M
Androgen Receptor, His•Tag®, Human, Recombinant, S. frugiperda, recombinant human, expressed in S. frugiperda,
Species
human
SRP2071
Androgen receptor (650-920), human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
EHU025951
MISSION® esiRNA, targeting human AR,
Species
human
EMU006201
MISSION® esiRNA, targeting mouse Ar,
Species
mouse