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512732

Parthenolide, Tanacetum parthenium

A cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties.

Synonym(s):

Parthenolide, Tanacetum parthenium

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50 MG

₪438.00

₪438.00

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About This Item

Empirical Formula (Hill Notation):
C15H20O3
CAS Number:
20554-84-1
Molecular Weight:
248.32
MDL number:
MFCD00134592
UNSPSC Code:
12352200
NACRES:
NA.77

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Quality Level

100

description

RTECS - LY4220000

Assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 100 mg/mL
ethanol: 20 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

O1[C@H]2[C@H]3OC(=O)C(=C)[C@@H]3CC\C(=C/CC[C@]21C)\C

InChI

1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5-/t11-,12-,13-,15+/m0/s1

InChI key

KTEXNACQROZXEV-QLIGOWBFSA-N

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This Item
645900374000499610
Parthenolide, Tanacetum parthenium A cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties.

Sigma-Aldrich

512732

Parthenolide, Tanacetum parthenium

Triptolide, Tripterygium wilfordii A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent.

Sigma-Aldrich

645900

Triptolide, Tripterygium wilfordii

Helenalin, A. chamissonis ssp. foliosa

Sigma-Aldrich

374000

Helenalin, A. chamissonis ssp. foliosa

(5Z)-7-Oxozeaenol, Curvularia sp. (5Z)-7-Oxozeaenol, CAS 66018-38-0, is a cell-permeable, highly potent, selective, irreversible, and ATP-competitive inhibitor of MAPKKK TAK1 activity (IC50 = 8 nM).

Sigma-Aldrich

499610

(5Z)-7-Oxozeaenol, Curvularia sp.

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥97% (HPLC)

form

solid

form

solid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 100 mg/mL, ethanol: 20 mg/mL

solubility

DMSO: 20 mg/mL

solubility

DMSO: 10 mg/mL

solubility

DMSO: 10 mg/mL, ethanol: 5 mg/mL

General description

A cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase.
A sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages
Product does not compete with ATP.
Reversible: no

Other Notes

Wong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375.
Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810.
Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737.
Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317

Hazard Classifications

Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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