48912-U

ProClin^™ 300

pkg of 50 mL

• NACRES: NA.21

Properties

• contains: Alkyl Carboxylate
• Quality Level: 300
• composition: CMIT/MIT, 3%
• packaging: pkg of 50 mL
• greener alternative product characteristics: Designing Safer Chemicals; Learn more about the Principles of Green Chemistry.
• matrix: Modified glycol
• operating pH range: 2.5-8.5
• greener alternative category: Aligned

Description

General description

ProClin^™ preservatives are water-soluble preparations of biocides that are generally used to increase the shelf life of reagents. ProClin^™ 300 comprises of 3% of 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) and 2-methyl-4-isothiazloin-3-one (MIT) in a salt-free proprietary glycol containing an alkly carboxylate stabilizer. It has a recommended working pH range as 2.5 - 8.5.

We are committed to bringing you greener alternative products, which adhere to one or more of The 12 Principles of Green Chemistry. ProClin^™ 300 is a biocide that is considered as a greener alternative to more toxic NaN₃. It gives better protection than NaN₃ and thus this product aligns with "Design for Safer chemicals". Click here for more information.

Application

For use in biological diagnostic assays and IVDs only

ProClin biocides are immediately microstatic upon contact with microbial organisms as a result of their ability to quickly penetrate cell membranes and inhibit specific enzymes crucial to cellular respiration. Multiple specific sites of ProClin toxicity prevent microorganisms from developing high levels of resistance, making ProClin highly efficient even over extended storage periods of your IVD components.

ProClin^™ 300 is suitable for preparation of different buffers like ELISA buffer, sample and substrate dilution buffers for Single-Molecule Arrays (Simoa assay) and Immunoenzymatic assay. Additionally, Proclin^™ may be used in preparing storage buffer to store beads coupled with coronavirus nucleocapsid protein for the serological multiplex assay.

Packaging

50 mL

Biochem/physiol Actions

ProClin^™ products contain active substances like CMIT and MIT which inhibit the Krebs cycle at four different check points, the enzymes pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, succinate dehydrogenase, and NADH dehydrogenase. The inhibition of Krebs cycle leads to effective broad-spectrum biocidal activity against bacteria, fungi, and yeast.

Linkage

For additional technical details on ProClin, including key features and mechanism of action, please visit www.sigmaaldrich.com/proclin.

Legal Information

ProClin is a trademark of The Dow Chemical Company or an affiliated company of Dow

Safety Information

• Pictograms: GHS05,GHS07,GHS09
• Signal Word: Danger
• Hazard Statements: H302 + H332 - H314 - H317 - H410
• Precautionary Statements: P273 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1
• Storage Class Code: 8A - Combustible, corrosive hazardous materials
• WGK: WGK 3
• Flash Point(F): 244.4 °F - closed cup
• Flash Point(C): 118 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves