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G5003

Sigma-Aldrich

α-Glucosidase from Saccharomyces cerevisiae

greener alternative

Type I, lyophilized powder, ≥10 units/mg protein (using p-nitrophenyl α-D-glucoside as substrate.)

Synonym(s):

α-D-Glucosidase, α-D-Glucoside glucohydrolase, Maltase from yeast

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About This Item

CAS Number:
Enzyme Commission number:
EC Number:
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.54

type

Type I

Quality Level

form

lyophilized powder

specific activity

≥10 units/mg protein (using p-nitrophenyl α-D-glucoside as substrate.)

contains

phosphate buffer salts and EDTA as balance

composition

Protein, ≥50%

greener alternative product characteristics

Waste Prevention
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

UniProt accession no.

foreign activity

β-Glucosidase, α−galactosidase and β−galactosidase ≤0.1%

greener alternative category

relevant disease(s)

diabetes (management of non-insulin-dependent diabetes mellitus)

storage temp.

−20°C

Gene Information

bakers yeast ... MAL12(853209) , MAL32(852602)

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General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for energy efficiency and waste prevention when used in starch hydrolysis research. For more information see the article in biofiles.

Application

α-glucosidase is used for the determination of α-amylase and the synthesis of various 1′-O-sucrose and 1-O-fructose esters. It was also used in the measurement of glycosidase inhibition.
For the determination of α-amylase and the synthesis of various 1′-O-sucrose and 1-O-fructose esters

Biochem/physiol Actions

α-glucosidase hydrolyzes carbohydrates by acting on 1,4-α linkages. Inhibition of α-glucosidase is a prominent target in the management of non-insulin-dependent diabetes mellitus.
Hydrolysis of terminal, non-reducing 1→4-linked D-glucose residues with release of D-glucose.

Packaging

Sold on basis of p-nitrophenyl α-D-glucoside units.

Unit Definition

One unit will liberate 1.0 μmole of D-glucose from p-nitrophenyl α-D-glucoside per min at pH 6.8 at 37 °C.

Analysis Note

Protein determined by biuret.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ivan Best et al.
Heliyon, 6(10), e05209-e05209 (2020-10-23)
Mauritia flexuosa L.f. is a palm tree which presents great morphological variability (morphotypes), represented mainly by the mesocarp color of its fruits. The objective of the study was to characterize the physicochemical and antioxidant properties of three morphotypes of Mauritia
M Bianchi
Anatomischer Anzeiger, 169(5), 351-366 (1989-01-01)
In 13 horses from both sexes, between 5 months and 18 years of age, in good nutritional state, statistical evaluations of fat cell sizes were performed in 16 body regions. From direct and indirect measurements referred to the cell diameter
Matusorn Wongon et al.
Heliyon, 6(3), e03458-e03458 (2020-03-11)
Long-term diabetic complications are exacerbated by post-prandial hyperglycemia which could be ameliorated by α-glucosidase inhibitor including oxyresveratrol. Puag-Haad is an aqueous extract from Artocarpus lakoocha Roxb. containing ~65% oxyresveratrol. Oxyresveratrol is an inhibitor of isolated yeast α-glucosidase enzyme but has
A D Baron
Diabetes research and clinical practice, 40 Suppl, S51-S55 (1998-09-18)
Fasting blood glucose level is usually used to diagnose diabetes, but is not a good predictor of postprandial hyperglycaemia, which is a more accurate measure of the metabolic defect underlying type 2 diabetes. Postprandial blood glucose levels may be elevated
Hypoglycemic Potential of Aqueous Extract of
Washim Khan et al.
Frontiers in pharmacology, 8, 577-577 (2017-09-29)

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