Benefiting from our leading bioprocess knowledge and engineering expertise in tangential flow filtration (TFF), we have developed multi-use, single-use, and process development systems incorporating many unique, innovative, and intelligent features. Our systems are designed to meet the success criteria for purification by tangential filtration, including low hold-up volume, maximum volume concentration, and optimal product recovery for enhanced process performance.
Mobius® FlexReady Solution for TFF provides a combination of single-use assemblies (Flexware® assemblies) and process-ready hardware specifically designed for TFF. It is pre-assembled and pre-tested, integrating easily into any process.
The Mobius® FlexReady Solution for TFF provides maximum adaptability to your changing process needs, such as varying volume levels. The retentate recycle tank is specifically designed for efficient concentration and diafiltration of proteins. Other key system features include:
The fully automated Cogent® Process-Scale TFF System is designed to separate and purify monoclonal antibodies, vaccines, plasma, and therapeutic proteins. It is ideally suited for both pilot and production scale applications, thereby supporting rapid scale-up from small- to large-scale operations. Other key system features include:
Our family of Cogent® Lab systems uses similar design, sensing technologies, and accessories as our manufacturing-scale equipment. With a homogeneous design and flow range from 20 to 6000 mL/min, our systems have been specifically created to simplify process development. The Cogent® Lab 150, 800, and 6000 systems are optimized for high product recovery and drainability, ensuring successful small-scale TFF operations.
Our systems are best suited for use with Pellicon® expendables, either in single-use (Pellicon® Capsule) or multi-use applications (Pellicon® 2 and 3). Holders may be included when purchasing a TFF system; please refer to the appropriate data sheet for details. We provide self-standing holders for filtration area from 88 cm² to 130 m² depending on expendables.
Options are available to increase the installed surface and run in single-pass mode.
Data Sheet: Cogent® Lab Systems
Spare Parts List - Cogent® Lab Systems
Data Sheet: Pellicon® Capsules with Ultracel® Membrane
Data Sheet: Pellicon® 3 Cassettes with Ultracel® Membrane
Data Sheet: Pellicon® 3 Cassettes with Biomax® Membrane
Data Sheet: Pellicon® 2 Filters and Holders
Data Sheet: Cogent® Process-scale Tangential Flow Filtration System
Data Sheet: Mobius® FlexReady Solution with Smart Flexware™ Assemblies for Chromatography and TFF
Data Sheet: Mobius® FlexReady Solution for TFF
Performance Guide: Mobius® FlexReady Solution (TF2S) with Smart Flexware® Assemblies for TFF with Closed Enabled Configuration
Spec. Sheet: Mobius® FlexReady Solution with Smart Flexware® Assemblies for TFF
Spare Parts List - Mobius® FlexReady Solution
Webinar: Optimize Your Ultrafiltration Process
Webinar: Single-use TFF Systems: The Value of Active Retentate Mixing
Webinar: Single-Use Tangential Flow Filtration for Closed Processing