Reaction design and optimization

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Chiral Phosphoric Acids: Versatile Organocatalysts with Expanding Applications

TRIP and TiPSY Chiral Phosphoric Acid Catalysts

BINOL and Derivatives

We present an article concerning BINOL and Derivatives.

ChiPros Chiral Alcohols

Chiral alcohols form a versatile class of chiral synthons, since they can be incorporated into the API structures directly as esters or ethers.

Phosgene and Phosgene Substitutes

Phosgene is 170 times more reactive than TP, the main phosgene substitute. Therefore, reactions with phosgene can be carried out under much milder conditions than with TP. Compounds will react faster and at lower temperatures (often at -78°C), preserving sensitive

Lithium Aminoborohydride (LAB) Reagents

Lithium aminoborohydride (LAB) reagents are a new class of powerful and selective reagents developed in the laboratory of Professor Bakthan Singaram at the University of California, Santa Cruz.

ChiPros Chiral Amines

Chiral amines play an important role in stereoselective organic synthesis. They are used directly as resolving agents, building blocks, or chiral auxiliaries.

Glycol Ethers Properties & Examples, Organic Solvents

Glycol ethers, with both an ether and alcohol functional group in the same molecule, are one of the most versatile classes of organic solvents.

Organic Azides and Azide Sources

Since the preparation of the first organic azide, phenyl azide, by Peter Griess in 1864 this energy-rich and versatile class of compounds has enjoyed considerable interest.

Sodium Triacetoxyborohydride

Sodium triacetoxyborohydride

Tetrakis(dimethylamino)ethylene (TDAE)

In 2001, Professor William Dolbier, Jr., at the University of Florida reported1 an approach to nucleophilic trifluoromethylation based on the generation of a trifluoromethyl anion using CF3I in the presence of a powerful twoelectron reductant, tetrakis(dimethylamino)ethylene (TDAE)

Chiral Amines in Asymmetric Synthesis

Chiral amines have found widespread application in asymmetric synthesis serving, for instance, as chiral bases in enantioselective deprotonation reactions or being valuable substances for resolving racemic mixtures of acids.

SyTracks Carbon Monoxide Generator FAQs

What is COgen? What is COware? What is the SyTracks COgenerator system? And more questions answered.

Greener Methods: Catalytic Amide Bond Formation

We are proud to offer a number of products used in catalytic amidation technology.

Spirocyclic Building Blocks for Scaffold Assembly

Spirocyclic modules containing four-membered rings are currently of growing interest to discovery chemists.

Verkade's Bases

Verkade's bases are used in a variety of organic reactions, such as alkylations, dehydrohalogenations, acylations, and condensation and organometallic reactions for carbon-carbon bond formation.

Traditional Strong and Hindered Bases

The basicity strength for some of our traditional bases, including DBU, DBN, and n-BuL are listed for easy comparison.

Functionalized Alkynes

Alkynes' versatility enables reactions like addition, metathesis, hydroboration, cleavage, coupling, and cycloadditions in synthetic chemistry.

Red-Al^® Reducing Agent

Red-Al® is a versatile and safe reducing agent, serving as a substitute for LiAlH4 in many reactions, with nonpyrophoric properties.

CBILS©: Cell-Based Immunotherapy Logistics System

CBILS© offers a simple, elegant synthetic method for the production of ionic liquids, developed by the Austrian company proionic.

Jacobsen Thioureas

Chiral thioureas serve as versatile organocatalysts, facilitating enantioselective reactions with a broad substrate scope.

Selective 1,2-Additions with LaCl3·2LiCl

Grignard reagent's 1,2-addition to ketones is powerful but selective issues often arise from competitive alpha-deprotonation.

Asymmetric Reduction of Ketones

Novel ligands enable efficient ketone reduction for chiral building block synthesis.

Maruoka Catalysts

Maruoka catalysts enable enantioselective preparation of α-amino acids from glycine derivatives via asymmetric phase transfer catalysis.

Chiral Diols

TADDOLs demonstrate versatility in metal-catalyzed asymmetric reactions and as Brønsted acid organocatalysts in hetero-Diels–Alder reactions.

Aldehydes as Building Blocks

Synthesis of selective aldosterone synthase inhibitors using Wittig reaction with heterocyclic aldehydes described in study by Hartmann et al.

Aerobic Alcohol Oxidation Solutions

Alcohol oxidation yields aldehydes and ketones, crucial intermediates in organic synthesis.

Inverse Electron Demand Diels-Alder Reactions

Inverse electron demand Diels-Alder reactions enable total synthesis of natural products with heteroaromatic ring systems.

Heterocyclic Aryne Precursors: New Opportunities for the Synthesis of Highly Substituted Indoles and Pyridines

New and efficient methods for the synthesis of functionalized heterocycles are highly sought after.

Preservation of Moisture-Sensitive Chemical Reagents

Preserve reagent quality of air- and moisture-sensitive reagents using nitrogen or argon in crown-cap bottles with a 6 mm diameter hole in the crown-cap and a PTFE-faced rubber liner.

Homobenzotetramisole (HBTM): A General Organocatalyst for Asymmetric Acylations

We are proud to offer the isothiourea organocatalyst homobenzotetramisole (HBTM) as part of our asymmetric catalysis portfolio in both (R) and (S) enantiomeric forms.

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