APP
amyloid beta (A4) precursor protein
Synonyms:
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
Species:
Human APP (351), Mouse App (11820), Rat App (54226), fruit fly app (39399), chicken APP (374198), dog APP (403407), domestic cat APP (101085564), cow APP (280722), sheep APP (101111593), domestic guinea pig App (100715302)
UniProtKB ID:
Gene ID:
- Human(351) Summary: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(11820) amyloid beta (A4) precursor protein
- Rat(54226) amyloid beta (A4) precursor protein
- fruit fly(39399) approximated
- chicken(374198) amyloid beta (A4) precursor protein
- dog(403407) amyloid beta (A4) precursor protein
- domestic cat(101085564) amyloid beta (A4) precursor protein
- cow(280722) amyloid beta (A4) precursor protein
- sheep(101111593) amyloid beta (A4) precursor protein
- domestic guinea pig(100715302) amyloid beta (A4) precursor protein
- naked mole-rat(101724743) amyloid beta (A4) precursor protein
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
ELISA
Product Number
Description
Species
Human APP / Amyloid Beta A4 Protein ELISA Kit, for serum, plasma, cell culture supernatants and urine,
Species
human
Small Molecule - Antagonist
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-APP (ab3) antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
immunohistochemistry
western blot
western blot
Anti-Phospho-APP-T668 antibody produced in rabbit, ,
Species Reactivity
mouse, rat
Application
western blot
Anti- APP antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-APP-C99 Antibody, clone mC99(70–80), ascites fluid, clone mC99(70-80), from mouse,
Species Reactivity
human, mouse
Application
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-APP Antibody, clone 1F22 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse, rat
Application
affinity binding assay
immunohistochemistry
western blot
immunohistochemistry
western blot
Proteins
Product Number
Description
Species