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Merck

8.52111

Fmoc-Lys(Me)2-OH HCl

≥95.0% (HPLC), for peptide synthesis, Novabiochem®

Synonym(s):

Fmoc-Lys(Me)₂-OH HCl, N-α-Fmoc-N-ε-dimethyl-N-L-lysine · hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C23H28N2O4 · xHCl
CAS Number:
Molecular Weight:
396.48 (free base basis)
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.22

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Product Name

Fmoc-Lys(Me)2-OH HCl, Novabiochem®

SMILES string

Cl.N([C@@H](CCCCN(C)C)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3

InChI

1S/C23H28N2O4.ClH/c1-25(2)14-8-7-13-21(22(26)27)24-23(28)29-15-20-18-11-5-3-9-16(18)17-10-4-6-12-19(17)20;/h3-6,9-12,20-21H,7-8,13-15H2,1-2H3,(H,24,28)(H,26,27);1H/t21-;/m0./s1

InChI key

SJFAFKDBWNFBCC-BOXHHOBZSA-N

product line

Novabiochem®

assay

≥95% (TLC)
≥95.0% (HPLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

amine

storage temp.

-10 to -25°C

Quality Level

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This Item
8.521128.521068.52065
form

powder

form

powder

form

powder

form

powder

assay

≥95% (TLC), ≥95.0% (HPLC)

assay

≥95% (TLC), ≥95.0% (HPLC)

assay

≥97.0% (HPLC), ≥98% (TLC)

assay

≥95.0% (acidimetric), ≥98% (TLC), ≥98.0% (HPLC)

functional group

amine

functional group

amine

functional group

amine

functional group

amine

product line

Novabiochem®

product line

Novabiochem®

product line

Novabiochem®

product line

Novabiochem®

storage temp.

-10 to -25°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(CMA1)): ≥ 95 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Acetate (IC): ≤ 1.0 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

General description

A novel derivative for the introduction of dimethyl-lysine during Fmoc SPPS. Ref [1] contains methods and protocols for the synthesis of arrays of histone-related peptides containing methylated arginine and lysine-residues.


Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS

Literature references

[1] S. Rothbart, et al. (2012) Methods Enzymol., 512, 107.

Other Notes

Replaces: 04-12-1269

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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Articles

Unnatural amino acids, the non-proteinogenic amino acids that either occur naturally or are chemically synthesized, are becoming more and more important as tools for modern drug discovery research.

Protocols

We provide an overview of our available reagents, together with recommendations and details of their use for synthesis of peptides containing post-translationally modified amino acids.

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