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00200595

Quercetin dihydrate

primary reference standard

Synonym(s):

2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one dihydrate, 3,3′,4′,5,7-Pentahydroxyflavone dihydrate

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Pack SizeSKUAvailabilityPrice
50 mg
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₹44,663.95

About This Item

Empirical Formula (Hill Notation):
C15H10O7 · 2H2O
CAS Number:
Molecular Weight:
338.27
EC Number:
204-187-1
UNSPSC Code:
85151701
NACRES:
NA.24
Colour Index Number:
75670
Beilstein/REAXYS Number:
317313

₹44,663.95


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grade

primary reference standard

form

powder

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

HWI

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

>300 °C (lit.)

SMILES string

OC(C(O)=C1)=CC=C1C2=C(O)C(C3=C(O)C=C(O)C=C3O2)=O

InChI

1S/C15H10O7.2H2O/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6;;/h1-5,16-19,21H;2*1H2

InChI key

GMGIWEZSKCNYSW-UHFFFAOYSA-N

General description

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Application

Reference standard in the analysis of herbal medicinal products.

Biochem/physiol Actions

Quercetin dihydrate is a flavonoid with anticancer activity.
Quercetin dihydrate is a flavonoid with anticancer activity. Quercetin is a mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin has antiproliferative effects on cancer cell lines, reduces cancer cell growth via type II estrogen receptors, and arrests human leukemic T cells in late G1 phase of the cell cycle.

Other Notes

This compound is commonly found in plants of the genus: allium angelica arnica carum echinacea eucalyptus ginkgo glycyrrhiza lycium pimpinella primula sambucus silybum

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PHL89263Y00010091592409
grade

primary reference standard

grade

primary reference standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

form

powder

form

powder

form

-

form

-

manufacturer/tradename

HWI

manufacturer/tradename

PhytoLab

manufacturer/tradename

EDQM

manufacturer/tradename

USP

mp

>300 °C (lit.)

mp

>300 °C (lit.)

mp

>300 °C (lit.)

mp

>300 °C (lit.)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

technique(s)

-

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

-

shelf life

-


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pictograms

Skull and crossbones

signalword

Danger

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2



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Tomohiko Matsuo et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(3), E311-E320 (2015-01-08)
Most mammals have two major olfactory subsystems: the main olfactory system (MOS) and vomeronasal system (VNS). It is now widely accepted that the range of pheromones that control social behaviors are processed by both the VNS and the MOS. However
Nada Oršolić et al.
European journal of nutrition, 53(5), 1217-1227 (2013-11-26)
Reactive oxygen species play a role in a number of degenerative conditions including osteoporosis. Flavonoids as phyto-oestrogens exert physiological effects against oxidative stress diseases. We developed a retinoic acid-induced bone loss model of rats to assess whether flavonoids and alendronate
Sameha Merzoug et al.
Naunyn-Schmiedeberg's archives of pharmacology, 387(10), 921-933 (2014-06-21)
This study was designed to evaluate the effect of quercetin, a natural flavonoid, on behavioral alterations, brain oxidative stress, and immune dysregulation caused by a chemotherapeutic agent, Adriamycin (ADR; 7 mg/kg of body weight). Different subsets of male Wistar rats were



Global Trade Item Number

SKUGTIN
00200595-50MG04061838602411

Questions

  1. What is the solubility, PKa, LogP, molecular weight and maximum absorption of 00200595 quercetin?

    1 answer
    1. The molecular weight of Quercetin hydrate is 302.24, on an anhydrous basis. The water content must be considered and is variable from lot to lot. The solubility, pKa, LogP, and absorption maximum are not determined. According to Drugbank the solubility in water is 261 ug/mL, the acidic pKa is 6.38 and the basic pKa is -4, and the LogP is 1.81 (per ALOGPS) and 2.16 (per Chemaxon). The absorbance maximum is not listed.

      See the link below for further information from Drugbank:
      https://go.drugbank.com/drugs/DB04216

      See the publication below for additional information on absorbance of Quercetin:
      https://www.jocpr.com/articles/determination-of-quercetin-by-uv-spectroscopy-as-quality-control-parameter-in-herbal-plant-cocculus-hirsutus.pdf

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