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Merck

B1116000

Biotin

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

D-Biotin, Bios II, Coenzyme R, Vitamin B7, Vitamin H

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About This Item

Empirical Formula (Hill Notation):
C10H16N2O3S
CAS Number:
58-85-5
Molecular Weight:
244.31
Beilstein:
86838
MDL number:
MFCD00005541
UNSPSC Code:
41116107
PubChem Substance ID:
329773165
NACRES:
NA.24

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biological source

synthetic

grade

pharmaceutical primary standard

Agency

EP

API family

biotin

form

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

231-233 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2

InChI

1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1

InChI key

YBJHBAHKTGYVGT-ZKWXMUAHSA-N

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1 of 4

This Item
PHR12331960691827
Biotin European Pharmacopoeia (EP) Reference Standard

B1116000

Biotin

Biotin Pharmaceutical Secondary Standard; Certified Reference Material

PHR1233

Biotin

Biotin tested according to Ph. Eur.

19606

Biotin

Biotin certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

91827

Biotin

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

clinical testing
pharmaceutical (small molecule)

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

HPLC: suitable, LC/MS: suitable, gas chromatography (GC): suitable

format

neat

format

neat

format

-

format

neat

form

solid

form

-

form

-

form

-

grade

pharmaceutical primary standard

grade

certified reference material, pharmaceutical secondary standard

grade

-

grade

certified reference material, TraceCERT®

storage temp.

2-8°C

storage temp.

2-30°C

storage temp.

-

storage temp.

2-8°C

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Biotin is a water-soluble vitamin B, which is involved in the synthesis of fatty acids and in gluconeogenesis.[1][2] It is found in plants and animals. Biotin deficiency causes retardation in growth, alopecia and neurological impairment in humans and animals.[3]

Application

Biotin may be used as an EP reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.[4][5]

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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