SAB5600095

Anti-Histone H3 K27M antibody, Rabbit Monoclonal

Name: Anti-Histone H3 K27M antibody, Rabbit Monoclonal
Brand: SIGMA
Price: 49048.08 INR
Availability: InStock

recombinant, expressed in HEK 293 cells, clone RM192, purified immunoglobulin

Synonym(s):

Anti-Histone H3 K27M, Histone H3 K27M Detection, Rabbit Anti-Histone H3 K27M

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SAB5600095-100UL

₹49,048.08

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Clone:

RM192, monoclonal, recombinant monoclonal

Species reactivity:

human

Application:

ELISA, ICC, IHC, WB

Citations:

Key Documents

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recombinant

expressed in HEK 293 cells

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

RM192, monoclonal, recombinant monoclonal

form

buffered aqueous glycerol solution

species reactivity

human

technique(s)

ELISA: 0.5-2 μg/mL, immunocytochemistry: 0.005-0.1 μg/mL, immunohistochemistry: 0.005-0.1 μg/mL, western blot: 0.01-1 μg/mL

isotype

IgG

NCBI accession no.

8350

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

mutation (Lys27Met)

Gene Information

human ... H3C1(8350)

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Show Differences

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This Item	SAB5600223	SAB5600011	SAB5600222
Sigma-Aldrich SAB5600095 Anti-Histone H3 K27M antibody, Rabbit Monoclonal	Sigma-Aldrich SAB5600223 Anti-Dimethyl-Histone H3 (Lys4) antibody, Rabbit monoclonal	Sigma-Aldrich SAB5600011 Anti-Dimethyl Histone H3 (Lys18) antibody, Rabbit monoclonal	Sigma-Aldrich SAB5600222 Anti-Acetyl-Histone H3 (Lys14) antibody, Rabbit monoclonal
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin
Gene Information human ... H3C1(8350)	Gene Information human ... H3C1(8350)	Gene Information human ... H3C1(8350)	Gene Information human ... H3C1(8350)
species reactivity human	species reactivity vertebrates	species reactivity human	species reactivity vertebrates
clone RM192, monoclonal, recombinant monoclonal	clone RM135, monoclonal, recombinant monoclonal	clone RM168, monoclonal, recombinant monoclonal	clone RM130, monoclonal, recombinant monoclonal
isotype IgG	isotype IgG	isotype IgG	isotype IgG
shipped in wet ice	shipped in wet ice	shipped in wet ice	shipped in wet ice

Immunogen

A peptide corresponding to Histone H3 K27M mutant.

Biochem/physiol Actions

This antibody reacts to the Histone H3 K27M mutant. No cross reactivity with wild type Histone H3.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 2

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Congenital tumors of the central nervous system: an institutional review of 64 cases with emphasis on tumors with unique histologic and molecular characteristics.

Angela N Viaene et al.

Brain pathology (Zurich, Switzerland), 31(1), 45-60 (2020-07-19)

Congenital brain tumors are rare accounting for 0.5%-1.9% of all pediatric brain tumors. While different criteria have been used to classify a tumor as congenital, those diagnosed prior to 6 months of age are considered to be "probably" congenital in origin.

The H3K27M mutation alters stem cell growth, epigenetic regulation, and differentiation potential.

N Kfoury-Beaumont et al.

BMC biology, 20(1), 124-124 (2022-06-01)

Neurodevelopmental disorders increase brain tumor risk, suggesting that normal brain development may have protective properties. Mutations in epigenetic regulators are common in pediatric brain tumors, highlighting a potentially central role for disrupted epigenetic regulation of normal brain development in tumorigenesis.

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