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Showing 1-30 of 804 results for "17-700" within Papers
Zhiming Dong et al.
Molecular cancer research : MCR, 15(7), 800-810 (2017-05-26)
Maternally expressed gene 3 (MEG3), a long non-coding RNA (lncRNA), has tumor-suppressor properties and its expression is lost in several human tumors. However, its biological role in esophageal squamous cell carcinoma (ESCC) tumorigenesis is poorly defined. The present study determined
Shufang Jin et al.
Molecular cancer, 21(1), 97-97 (2022-04-10)
N6-methyladenosine (m6A) RNA modification plays a critical role in various physiological and pathological conditions. However, the role of m6A modification in head and neck squamous cell carcinoma (HNSCC) remains elusive. In this study, the expression of m6A demethylases was detected
Qiyi Zhao et al.
Cell, 183(1), 76-93 (2020-09-16)
Mitochondria, which play central roles in immunometabolic diseases, have their own genome. However, the functions of mitochondria-located noncoding RNAs are largely unknown due to the absence of a specific delivery system. By circular RNA (circRNA) expression profile analysis of liver
Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation.
Nakamura, S; Kahyo, T; Tao, H; Shibata, K; Kurabe, N; Yamada, H; Shinmura, K; Ohnishi et al.
Scientific Reports null
Yongchao Liu et al.
Scientific reports, 5, 10159-10159 (2015-05-12)
Long non-coding RNAs (lncRNAs), which have evolved as important gene expression modulators, are involved in human malignancies. The down-regulation of lncRNA growth arrest specific transcript 5 (GAS5) has been reported in several cancers, however, the underlying mechanism of lncRNA GAS5
Tian Lan et al.
Journal of experimental & clinical cancer research : CR, 36(1), 11-11 (2017-01-12)
Hepatocellular carcinoma (HCC) is third leading cause of cancer-related death globally. Evidence suggest that long non-coding RNAs (lncRNAs) have emerged as key regulators of tumorigenesis and metastasis in HCC. In this study, we investigated the functional significance of SNHG12 and
Shekhar Saha et al.
Cancer research, 80(5), 950-963 (2020-01-05)
DRAIC is a 1.7 kb spliced long noncoding RNA downregulated in castration-resistant advanced prostate cancer. Decreased DRAIC expression predicts poor patient outcome in prostate and seven other cancers, while increased DRAIC represses growth of xenografted tumors. Here, we show that
The lncRNA PVT1 Contributes to the Cervical Cancer Phenotype and Associates with Poor Patient Prognosis.
Iden, M; Fye, S; Li, K; Chowdhury, T; Ramchandran, R; Rader, JS
Testing null
Archana D Siddam et al.
PLoS genetics, 14(3), e1007278-e1007278 (2018-03-23)
Opacification of the ocular lens, termed cataract, is a common cause of blindness. To become transparent, lens fiber cells undergo degradation of their organelles, including their nuclei, presenting a fundamental question: does signaling/transcription sufficiently explain differentiation of cells progressing toward
Dietary lipids modulate the expression of miR-107, an miRNA that regulates the circadian system.
Daimiel-Ruiz, L; Klett-Mingo, M; Konstantinidou, V; Mico, V; Aranda, JF; Garcia et al.
Molecular Nutrition And Food Research null
Fang Shen et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 41(3), 530-545 (2020-04-07)
RNA-binding protein fox-1 homolog 1 (Rbfox-1), an RNA-binding protein in neurons, is thought to be associated with many neurological diseases. To date, the mechanism on which Rbfox-1 worsens secondary cell death in ICH remains poorly understood. In this study, we
Oncogenic NRAS, required for pathogenesis of embryonic rhabdomyosarcoma, relies upon the HMGA2-IGF2BP2 pathway.
Li, Z; Zhang, Y; Ramanujan, K; Ma, Y; Kirsch, DG; Glass, DJ
Cancer research null
Rong Qiu et al.
Journal of immunology (Baltimore, Md. : 1950), 204(12), 3160-3170 (2020-05-18)
It is well known that some pathogenic cells have enhanced glycolysis; the regulatory network leading to increased glycolysis are not well characterized. In this study, we show that CNS-infiltrated pathogenic TH17 cells from diseased mice specifically upregulate glycolytic pathway genes
Xueying Yang et al.
Cell death & disease, 12(5), 462-462 (2021-05-10)
FTO removes the N6-methyladenosine (m6A) modification from genes and plays a critical role in cancer development. However, the mechanisms underlying the regulation of FTO and its subsequent impact on the regulation of the epitranscriptome remain to be further elucidated. Here
Long non-coding RNA LINC00672 contributes to p53 protein-mediated gene suppression and promotes endometrial cancer chemosensitivity.
Li, W; Li, H; Zhang, L; Hu, M; Li, F; Deng, J; An, M; Wu, S; Ma, R; Lu, J; Zhou, Y
The Journal of Biological Chemistry null
TET-Mediated Sequestration of miR-26 Drives EZH2 Expression and Gastric Carcinogenesis.
Deng, M; Zhang, R; He, Z; Qiu, Q; Lu, X; Yin, J; Liu, H; Jia, X; He, Z
Cancer Research null
Qi Yang et al.
PLoS genetics, 8(12), e1003172-e1003172 (2013-01-10)
Fragile X syndrome (FXS) is a form of inherited mental retardation in humans that results from expansion of a CGG repeat in the Fmr1 gene. Recent studies suggest a role of astrocytes in neuronal development. However, the mechanisms involved in
Cloning of the quail PIWI gene and characterization of PIWI binding to small RNAs.
Chen, R; Chang, G; Zhang, Y; Dai, A; Ma, T; Li, J; Zhai, F; Hua, D; Xia, M; Chen, G
Testing null
LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription.
Liu, CY; Zhang, YH; Li, RB; Zhou, LY; An, T; Zhang, RC; Zhai, M; Huang, Y; Yan, KW; Dong et al.
Nature Communications null
Fang Zheng et al.
Nature communications, 12(1), 1341-1341 (2021-02-28)
Hypoxia-inducible factor-1 (HIF-1) is a master driver of glucose metabolism in cancer cells. Here, we demonstrate that a HIF-1α anti-sense lncRNA, HIFAL, is essential for maintaining and enhancing HIF-1α-mediated transactivation and glycolysis. Mechanistically, HIFAL recruits prolyl hydroxylase 3 (PHD3) to
Gongchao Wang et al.
American journal of cancer research, 5(10), 3162-3173 (2015-12-23)
Lung adenocarcinoma (LAD) and lung squamous cell cancer (LSCC) are two most common histological types of lung cancer, while they differ in many aspects. Recent evidence shows that long non-coding RNAs (lncRNAs) play an important role in the process of
Chunling Luo et al.
Cancer research, 77(5), 1168-1178 (2017-01-14)
Aberrant RNA splicing is recognized to contribute to cancer pathogenesis, but the underlying mechanisms remain mainly obscure. Here, we report that the splicing factor SRSF2 is upregulated frequently in human hepatocellular carcinoma (HCC), where this event is associated with poor
Fudi Zhong et al.
Nucleic acids research, 43(21), 10474-10491 (2015-09-26)
PIWI interacting RNAs (piRNAs) are highly expressed in germline cells and are involved in maintaining genome integrity by silencing transposons. These are also involved in DNA/histone methylation and gene expression regulation in somatic cells of invertebrates. The functions of piRNAs
Wei Liu et al.
Experimental and therapeutic medicine, 22(3), 1041-1041 (2021-08-11)
Increasing evidence demonstrates that dysregulation of microRNAs (miRNAs/miRs) is implicated in the development of colorectal cancer. However, the biological functions of several differentially expressed miRNAs remain unknown. In the present study, a bioinformatic analysis of a previously published microarray data
Sole Gatto et al.
Nucleic acids research, 45(10), 5739-5756 (2017-03-24)
Hypomorphic mutations in DNA-methyltransferase DNMT3B cause majority of the rare disorder Immunodeficiency, Centromere instability and Facial anomalies syndrome cases (ICF1). By unspecified mechanisms, mutant-DNMT3B interferes with lymphoid-specific pathways resulting in immune response defects. Interestingly, recent findings report that DNMT3B shapes
Ling Jin et al.
Hypertension (Dallas, Tex. : 1979), 71(2), 262-272 (2017-12-28)
Recent studies reported some long noncoding RNAs (lncRNAs)-mediated vascular smooth muscle cells (VSMCs) phenotypic switch, which was a common pathophysiological process of vascular diseases. However, whether human-specific expressed lncRNAs would modulate VSMCs phenotype and participate into the pathogenesis of essential
Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression.
Zhang, J; Liu, H; Hou, L; Wang, G; Zhang, R; Huang, Y; Chen, X; Zhu, J
Molecular Cancer null
Cunjie Chang et al.
Nature communications, 13(1), 1363-1363 (2022-03-18)
Deregulation of alternative splicing is implicated as a relevant source of molecular heterogeneity in cancer. However, the targets and intrinsic mechanisms of splicing in hepatocarcinogenesis are largely unknown. Here, we report a functional impact of a Splicing Regulatory Glutamine/Lysine-Rich Protein
Guohua Lü et al.
Aging, 12(4), 3218-3237 (2020-02-18)
Chondrocyte apoptosis and extracellular matrix (ECM) degeneration have been implicated in the pathogenesis of osteoarthritis (OA). Based on previously reported microarray analysis, HRAS (Harvey rat sarcoma viral oncogene homolog), a member of the RAS protein family, was chosen as a
Deepak Parashar et al.
Cell reports, 29(13), 4389-4406 (2019-12-26)
Genomic amplification of 3q26.2 locus leads to the increased expression of microRNA 551b-3p (miR551b-3p) in triple-negative breast cancer (TNBC). Our results demonstrate that miR551b-3p translocates to the nucleus with the aid of importin-8 (IPO8) and activates STAT3 transcription. As a consequence
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