HomeWebinarsOvercoming Viscosity Challenges in High Concentration Tangential Flow Filtration (TFF)

Overcoming Viscosity Challenges in High Concentration Tangential Flow Filtration (TFF)


Viscosity is one major challenge in manufacturing and formulating highly concentrated antibody drug products suitable for subcutaneous injection. Especially during concentration steps in downstream processing, attractive interactions and resulting high viscosity bear challenges that can limit the maximum protein concentration. The selection of suitable tangential flow filtration (TFF) cassettes, paired with the Viscosity Reduction Platform, consisting of viscosity-modifying excipient combinations that provide a tailored solution to address viscosity issues, enables significantly higher target protein concentrations with improved processing economics.

In this webinar, you will learn:

  • Challenges arising from highly concentrated protein solutions during formulation by TFF
  • The impact of TFF cassette design
  • Benefits of viscosity-reducing excipient combination during TFF


Tobias Rosenkranz, Ph.D.

Tobias Rosenkranz, Ph.D.


Senior Manager, Biomolecule Formulation R&D

Tobias Rosenkranz heads the biomolecule formulation team in the liquid formulation R&D department in Darmstadt. His lab mainly focuses on formulation challenges arising in protein formulations, such as protein viscosity and aggregation. A biophysicist by training, he holds a Ph.D. from the HHU Düsseldorf/Research Centre Jülich. Prior to joining the company in 2017, Tobias was a basic researcher at UIUC (US) and UNSW Australia.

Gerd Walter

Gerd Walter


Director, Customer Application, Downstream, EMEA

Gerd Walter is a director in customer application, downstream, with more than 25 years of experience. He has a wide range of biotech knowledge on mAbs, recombinant proteins, vaccines, VGT, plasma, classical pharma, as well as cGMP understanding from upstream to downstream and final filling.

Webinar Information

Pharma and biopharma manufacturing

  • Liquid Formulation Strategies
  • Duration:40min

  • Language:English

  • Session 1:presented May 19, 2022

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