- Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.
Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.
Journal of inorganic biochemistry (2011-11-22)
Joseph Lemire, Vasu D Appanna
PMID22099161
ABSTRACT
Aluminum (Al) has been implicated in a variety of neurological diseases. However, the molecular mechanisms that enable Al to be involved in these disorders have yet to be fully delineated. Using astrocytes as a model of the cerebral cellular system, we have uncovered the biochemical networks that are affected by Al toxicity. In this review, we reveal how the inhibitory influence of Al on ATP production and on mitochondrial functions help generate globular astrocytes that are fat producing machines. These biological events may be the contributing factors to Al-triggered brain disorders.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Aluminum, evaporation slug, diam. × L 6.3 mm × 6.3 mm, 99.999% trace metals basis
Aluminum, honeycomb, 600x600mm, thickness 20mm, cell size 3.2mm, cell wall 0.025mm, core density 0.072g/cm3, phenolic adhesive (resin), 99.5%
Aluminum, honeycomb, 300x300mm, thickness 5mm, cell size 19mm, cell wall 0.064mm, core density 0.029g/cm3, phenolic adhesive (resin), 99.5%
Aluminum, honeycomb, 600x600mm, thickness 26.5mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm3, phenolic adhesive (resin), facing skin carbon fiber / epoxy, 99.9%
Aluminum, honeycomb, 300x300mm, thickness 20mm, cell size 4.8mm, cell wall 0.038mm, core density 0.070g/cm3, phenolic adhesive (resin), 99.5%
Aluminum, honeycomb, 600x600mm, thickness 10mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm3, phenolic adhesive (resin), 99.5%
Aluminum, IRMM®, certified reference material, 1.0 mm foil
Aluminum, IRMM®, certified reference material, 1.0 mm wire
Aluminum, wire reel, 50m, diameter 0.25mm, hard, 99.99+%
Aluminum, wire reel, 5m, diameter 2.0mm, as drawn, 99.999%
Aluminum, microleaf disks, 25mm, thinness 1.0μm, specific density 269.9μg/cm2, removable support, 99.999%
Aluminum, microfoil, disks, 50mm, thinness 1.0μm, specific density 269.9μg/cm2, permanent mylar 3.5μm support, 99.999%
Aluminum, tube, 0.5m coil, as drawn, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, 99.5%
Aluminum, tube, 100mm, outside diameter 0.55mm, inside diameter 0.4mm, wall thickness 0.075mm, as drawn, 99.5%
Aluminum, mesh, 150x150mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh
Aluminum, tube, 200mm, outside diameter 1.42mm, inside diameter 1.166mm, wall thickness 0.127mm, as drawn, 99.5%
Aluminum, rod, 100mm, diameter 28mm, as drawn, 99.999%
Aluminum, rod, 50mm, diameter 28mm, as drawn, 99.999%
Aluminum, rod, 500mm, diameter 5.0mm, as drawn, 99.999%
Aluminum, sphere, 100pcs, diameter 3.0mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%
Aluminum, microleaf disks, 25mm, thinness 0.15μm, specific density 41.28μg/cm2, removable support, 99.999%
Aluminum, microleaf disks, 10mm, thinness 1.0μm, specific density 269.9μg/cm2, removable support, 99.999%
Aluminum, rod, 100mm, diameter 12.0mm, as drawn, 99.999%