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  • Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.

Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.

Journal of inorganic biochemistry (2011-11-22)
Joseph Lemire, Vasu D Appanna
ABSTRACT

Aluminum (Al) has been implicated in a variety of neurological diseases. However, the molecular mechanisms that enable Al to be involved in these disorders have yet to be fully delineated. Using astrocytes as a model of the cerebral cellular system, we have uncovered the biochemical networks that are affected by Al toxicity. In this review, we reveal how the inhibitory influence of Al on ATP production and on mitochondrial functions help generate globular astrocytes that are fat producing machines. These biological events may be the contributing factors to Al-triggered brain disorders.

MATERIALS
Product Number
Brand
Product Description

Aluminum, foam, 33x140mm, thickness 20mm, bulk density 0.2g/cm3, porosity 0.93, aluminum 6101 grade, 98.5%
Aluminum, honeycomb, 150x150mm, thickness 10mm, cell size 3.2mm, cell wall 0.025mm, core density 0g/cm3, phenolic adhesive (resin), 99.5%
Aluminum, foam, 150x150mm, thickness 10mm, bulk density 0.2g/cm3, porosity 0.93, aluminum 6101 grade, 98.5%
Aluminum, honeycomb, 600x600mm, thickness 26.5mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm3, phenolic adhesive (resin), facing skin glass fiber 0.5mm, 99.9%
Aluminum, foam, 150x150mm, thickness 6.35mm, bulk density 0.2g/cm3, porosity 0.93, 4 pores/cm, aluminum 6101 grade, 98.5%
Aluminum, honeycomb, 600x600mm, thickness 13.9mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm3, phenolic adhesive (resin), facing skin aluminum 0.55mm, 99.9%
Aluminum, honeycomb, 300x300mm, thickness 10mm, cell size 3.2mm, cell wall 0.025mm, core density 0g/cm3, phenolic adhesive (resin), 99.5%
Aluminum, foam, 150x150mm, thickness 3.2mm, bulk density 0.2g/cm3, porosity 0.93, 16 pores/cm, aluminum 6101 grade, 98.5%
Aluminum, honeycomb, 300x300mm, thickness 26.5mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm3, phenolic adhesive (resin), facing skin glass fiber 0.5mm, 99.9%
Aluminum, foam, 150x150mm, thickness 6.35mm, bulk density 0.2g/cm3, porosity 0.93, 16 pores/cm, aluminum 6101 grade, 98.5%
Aluminum, honeycomb, 600x600mm, thickness 20mm, cell size 4.8mm, cell wall 0.038mm, core density 0.070g/cm3, phenolic adhesive (resin), 99.5%
Aluminum, tube, 200mm, outside diameter 0.6mm, inside diameter 0.3mm, wall thickness 0.15mm, as drawn, 99.5%
Aluminum, microfoil, disks, 10mm, thinness 1.0μm, specific density 269.9μg/cm2, permanent mylar 3.5μm support, 99.999%
Aluminum, tube, 500mm, outside diameter 1.42mm, inside diameter 1.166mm, wall thickness 0.127mm, as drawn, 99.5%
Aluminum, rod, 50mm, diameter 30.0mm, as drawn, 99.999%
Aluminum, rod, 1000mm, diameter 12.0mm, as drawn, 99.999%
Aluminum, honeycomb, 300x300mm, thickness 5mm, cell size 3.2mm, cell wall 0.025mm, core density 0.072g/cm3, phenolic adhesive (resin), 99.5%
Aluminum, honeycomb, 300x300mm, thickness 20mm, cell size 3.2mm, cell wall 0.025mm, core density 0.072g/cm3, phenolic adhesive (resin), 99.5%
Aluminum, honeycomb, 600x600mm, thickness 10mm, cell size 3.2mm, cell wall 0.025mm, core density 0g/cm3, phenolic adhesive (resin), 99.5%
Aluminum, microleaf disks, 10mm, thinness 0.15μm, specific density 41.28μg/cm2, removable support, 99.999%
Aluminum, mesh, 300x300mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh
Aluminum, tube, 500mm, outside diameter 1.96mm, inside diameter 1.4mm, wall thickness 0.28mm, as drawn, 99.5%
Aluminum, insulated wire, 10m, conductor diameter 0.1mm, insulation thickness 0.005mm, polyimide insulation, 99.95+%
Aluminum, rod, 1000mm, diameter 10.0mm, as drawn, 99.999%
Aluminum, rod, 1000mm, diameter 12.7mm, 99%
Aluminum, microleaf disks, 10mm, thinness 0.25μm, specific density 68.8μg/cm2, removable support, 99.999%
Aluminum, rod, 50mm, diameter 20.0mm, as drawn, 99.999%
Aluminum, rod, 200mm, diameter 6.0mm, as drawn, 99.999%
Aluminum, rod, 1000mm, diameter 5.0mm, as drawn, 99.999%
Aluminum, microleaf disks, 10mm, thinness 0.5μm, specific density 120.6μg/cm2, removable support, 99.999%