Mechanistic studies on the reactions of platinum(II) complexes with nitrogen- and sulfur-donor biomolecules.

Mechanistic studies on the reactions of platinum(II) complexes with nitrogen- and sulfur-donor biomolecules.

Dalton transactions (Cambridge, England : 2003) (2012-08-15)

Živadin D Bugarčić, Jovana Bogojeski, Biljana Petrović, Stephanie Hochreuther, Rudi van Eldik

ABSTRACT

A brief overview of mechanistic studies on the reactions of different Pt(II) complexes with nitrogen- and sulfur-donor biomolecules is presented. The first part describes the results obtained for substitution reactions of mono-functional Pt(II) complexes with different biomolecules, under various experimental conditions (temperature, pH and ionic strength). In addition, an overview of the results obtained for the substitution reactions of bi-functional Pt(II) complexes, analogous to cisplatin, with biomolecules is given. The last part of this report deals with different polynuclear Pt(II) complexes and their substitution behaviour with different biomolecules. The purpose of this perspective is to improve the understanding of the mechanism of action of Pt(II) complexes as potential anti-tumour drugs in the human body.

MATERIALS

Product Number

Brand

Product Description

685453

Sigma-Aldrich

Platinum, nanopowder, <50 nm particle size (TEM)

373265

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, thermocouple grade

349356

Sigma-Aldrich

Platinum, foil, thickness 0.05 mm, 99.99% trace metals basis

344621

Sigma-Aldrich

Sulfur, flakes, ≥99.99% trace metals basis

357367

Sigma-Aldrich

Platinum, wire, diam. 0.10 mm, 99.99% trace metals basis

327433

Sigma-Aldrich

Platinum, foil, thickness 0.125-0.135 mm, 99.9% trace metals basis

357359

Sigma-Aldrich

Platinum, wire, diam. 0.20 mm, ≥99.99% trace metals basis

267228

Sigma-Aldrich

Platinum, wire, diam. 0.5 mm, 99.9% trace metals basis

267201

Sigma-Aldrich

Platinum, wire, diam. 0.5 mm, 99.99% trace metals basis

327492

Sigma-Aldrich

Platinum, wire, diam. 1.0 mm, 99.9% trace metals basis

267171

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.99% trace metals basis

267260

Sigma-Aldrich

Platinum, foil, thickness 0.5 mm, 99.99% trace metals basis

267163

Sigma-Aldrich

Platinum, wire, diam. 0.127 mm, 99.99% trace metals basis

267155

Sigma-Aldrich

Platinum, sponge, ≥99.9% trace metals basis

204048

Sigma-Aldrich

Platinum, powder (coarse), 99.99% trace metals basis

36576

Supelco

Sulfur, PESTANAL^®, analytical standard

298107

Sigma-Aldrich

Platinum, gauze, 52 mesh, 99.9% trace metals basis

204013

Sigma-Aldrich

Platinum, powder, 99.995% trace metals basis

303798

Sigma-Aldrich

Platinum, foil, thickness 0.05 mm, ≥99.9% trace metals basis

373214

Sigma-Aldrich

Platinum, evaporation slug, diam. × L 0.6 cm × 1.2 cm, 99.99% trace metals basis

414980

Sigma-Aldrich

Sulfur, powder, 99.98% trace metals basis

349372

Sigma-Aldrich

Platinum, foil, thickness 1.0 mm, 99.99% trace metals basis

349399

Sigma-Aldrich

Platinum, wire, diam. 1.5 mm, ≥99.9% trace metals basis

349364

Sigma-Aldrich

Platinum, foil, thickness 0.025 mm, 99.99% trace metals basis

GF84918044

Platinum, insulated wire, 0.5m, conductor diameter 0.018mm, insulation thickness 0.002mm, polyester insulation, 99.99%

GF48427601

Platinum, foil, not light tested, 50x50mm, thickness 0.002mm, as rolled, 99.95%

GF48886228

Platinum, insulated wire, 0.2m, conductor diameter 0.125mm, insulation thickness 0.016mm, PTFE (polytetrafluoroethylene) insulation, 99.99%

GF08303330

Platinum, insulated wire, 1m, conductor diameter 0.025mm, insulation thickness 0.005mm, polyester insulation, 99.99%

GF39266422

Platinum, insulated wire, 0.5m, conductor diameter 0.025mm, insulation thickness 0.005mm, polyester insulation, 99.99%

GF25082872

Platinum, insulated wire, 1m, conductor diameter 0.025mm, insulation thickness 0.005mm, polyimide insulation, 99.99%